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Axonal lamin B2 (LB2) associates with mitochondria, and LB2-deficient axons exhibit mitochondrial dysfunction and defects in axonal transport
LIII filaments appear identical to the endogenous lamina, whereas lamin B2 assembles into filaments that are organized less precisely; Lamin A (show LMNA Proteins) induces sheets of thicker filaments on the endogenous lamina and increases the rigidity of the nuclear envelope
our studies strongly implicate an overarching role for Lamin B2 in the maintenance of nuclear architecture since loss of Lamin B2 relieves the spatial positional constraints required for maintaining conserved localization of aneuploid chromosome territories in the interphase nucleus.
Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia.
Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin (show LMNA Proteins) isoform.
Treating normal human fibroblasts with farnesyltransferase inhibitors causes the accumulation of unprocessed lamin B2 and lamin A (show LMNA Proteins) and a decrease in mature lamin B1 (show LMNB1 Proteins)
Mutation in LMNB2 gene is associated with partial lipodystrophy.
Studies indicate that the lamin (show LMNA Proteins)-binding proteins implicated in laminopathies include lamin B2 and nuclear envelope proteins.
These findings indicate that a lamin (show LMNA Proteins) dimer principally has the freedom for a "combinatorial" head-to-tail association with all types of lamins, a property that might be of significant importance for the assembly of the nuclear lamina.
analysis of protein-DNA interactions at the human lamin B2 replication origin
The proteins bound in vivo at the LMNB2 replication origin were investigated along the cell cycle.
This analysis reveals the modular structure of the lamin B2 origin and supports the idea that sequence elements close to the replication start site play an important role in origin activation.
Lamin B2 may play a key role in nuclear translocation.
Lamin B2 is essential for brain development and is important for resistance to nuclear elongation in neurons.
Absence of both Lmnb1 (show LMNB1 Proteins) and Lmnb2 in keratinocytes has no effect on cell proliferation or the development of skin and hair.
These studies establish an essential function for lamin B2 in neuronal migration and brain development.
Evidence suggests that germ line-specific lamin B3 reduces the stability of the nuclear periphery due to its shortened rod domain.
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy.
, lamin LII
, lamin B3