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|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) Antibodies|
|Conjugate||This TNFRSF10A antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-TNFRSF10A AntibodyTarget Details TNFRSF10A Application Details Handling Images
|Specificity||DR4 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR4 protein.|
|Immunogen||Human DR4 (C-Terminus) Peptide|
Target Details TNFRSF10AProduct Details anti-TNFRSF10A Antibody Application Details Handling Images back to top
|Alternative Name||CD261 / TRAILR1 (TNFRSF10A Antibody Abstract)|
|Background||Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL2,3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappaB activation in many tissues and cells.Synonyms: APO2, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, Tumor necrosis factor receptor superfamily member 10A|
|Research Area||Apoptosis/Necrosis, Signaling|
|Pathways||Apoptosis, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Handling Images back to top
ELISA. Western Blot: 1/500 to 1/1000. A 57 kDa band should be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|