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|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies|
|Conjugate||This TNFRSF12A antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-TNFRSF12A AntibodyTarget Details TNFRSF12A Application Details Handling Images
|Specificity||This antibody reacts with TWEAKR.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Immunogen||Human IgG1 Fc-tagged Fn14 protein.|
|Plasmids, Primers & others|
Target Details TNFRSF12AProduct Details anti-TNFRSF12A Antibody Application Details Handling Images back to top
|Alternative Name||CD266 / TweakR (TNFRSF12A Antibody Abstract)|
|Background||TWEAKR (known as TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A), is a member of the TNF family and was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library.Synonyms: FGF-inducible 14, FN14, Fibroblast growth factor-inducible immediate-early response protein 14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Tweak receptor|
|Pathways||Apoptosis, Regulation of Cell Size|
Application DetailsProduct Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Handling Images back to top
Western Blo: 1 μg/mL. Immunohistochemistry on Paraffin Sections: 2.5 μg/mL. This antibody was validated for use in immunohistochemistry on a panel of 21formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigenretrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides wereincubated with biotinylated secondary antibody, followed by alkalinephosphatase-streptavidin and chromogen. The stained slides were evaluated by apathologist to confirm staining specificity.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Images back to top
|Buffer||Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.|
ImagesProduct Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling back to top