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|Antigen||X-Linked Inhibitor of Apoptosis (XIAP) Antibodies|
|Epitope||AA 75-226 Alternatives|
|Conjugate||This XIAP antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-XIAP AntibodyTarget Details XIAP Application Details Handling Images
|Specificity||This antibody reacts to X-linked Inhibitor Of Apoptosis Protein XIAP (XIAP/BIRC4).|
Species reactivity (expected):Mouse (88 %), Rat (90 %), Rabbit (94 %), Pig (92 %).
Species reactivity (tested):Human.
|Immunogen||Recombinant protein fragment containing a sequence corresponding to a region within amino acids 75 and 226 of BIRC4. Genename: XIAP|
Target Details XIAPProduct Details anti-XIAP Antibody Application Details Handling Images back to top
|Alternative Name||IAP3 / BIRC4 (XIAP Antibody Abstract)|
|Background||Apoptosis inhibitor 3 (API3) is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, API3 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. API3 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.Synonyms: API3, Baculoviral IAP repeat-containing protein 4, E3 ubiquitin-protein ligase XIAP, HILP, Inhibitor of apoptosis protein 3, X-linked IAP, X-linked inhibitor of apoptosis protein, XIAP|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis|
Application DetailsProduct Details anti-XIAP Antibody Target Details XIAP Handling Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-XIAP Antibody Target Details XIAP Application Details Images back to top
|Buffer||0.1 M Tris-Glycine, pH 7.0 containing 10 % Glycerol and 0.01 % Thimerosal|
|Precaution of Use||This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
ImagesProduct Details anti-XIAP Antibody Target Details XIAP Application Details Handling back to top