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Stargardt Disease

Stargardt disease (STGD) is the most prevalent inherited macular dystrophy and is associated with disease-causing sequence variants in the gene ABCA4. Significant advances have been made over the last 10 years in our understanding of both the clinical and molecular features of STGD1, and also the underlying pathophysiology, which has culminated in ongoing and planned human clinical trials of novel therapies.(1) Mutations in four genes have been linked with Stargardt disease: ABCA4, ELOVL4, PROM1, CNGB3.

ABCA4 Antibody cited in Stargardt Disease Gene Therapy Article

McClements et al. investigate use of dual vector approach for AAV Gene Therapy of Stargardt disease. anti-ABCA4 antibody (ABIN343052) cited in Human Gene Therapy Vol. 30, No. 5. (2019)

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Important Targets related to Stargardt disease

The following targets are directly related to research on Stargardt disease. Click on the links to see available antibodies, kits, proteins, and tools.

ABCA4 Antibodies

Autosomal recessive retinal diseases caused by mutations in the ABCA4 gene are being considered for gene replacement therapy. All individuals with ABCA4-disease show macular degeneration.(2)

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityCow
ClonalityMonoclonal
ApplicationIHC, WB
Cat. No.ABIN361347
Quantity100 μL
ReactivityHuman
ClonalityPolyclonal
ApplicationELISA, WB
Cat. No.ABIN343052
Quantity100 μg

ELOVL4 Antibodies

Autosomal dominant Stargardt macular dystrophy caused by mutations in the Elongation of Very Long Chain fatty acids (ELOVL4) gene results in macular degeneration, leading to early childhood blindness.(3)

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityHuman
ClonalityPolyclonal
ApplicationWB
Cat. No.ABIN1679709
Quantity100 μg
ReactivityHuman, Mouse
ClonalityPolyclonal
ApplicationELISA, ICC, IF, WB
Cat. No.ABIN6258771
Quantity100 μL
ReactivityHuman, Mouse
ClonalityPolyclonal
ApplicationELISA, WB
Cat. No.ABIN3184467
Quantity100 μL

PROM1 Antibodies

Prominin-1 (Prom1) is a transmembrane glycoprotein, which is expressed in stem cell lineages, and has recently been implicated in cancer stem cell survival. Mutations in the Prom1 gene have been shown to disrupt photoreceptor disk morphogenesis and cause an autosomal dominant form of Stargardt-like macular dystrophy (STGD4).(4)

Product
Reactivity
Clonality
Application
Cat. No.
Quantity
ReactivityHuman
ClonalityMonoclonal
ApplicationFACS, ICC, WB
Cat. No.ABIN6559826
Quantity100 tests
ReactivityHuman
ClonalityMonoclonal
ApplicationFACS, IHC, WB
Cat. No.ABIN6559814
Quantity0.1 mg
ReactivityHuman
ClonalityMonoclonal
ApplicationFACS, IHC, WB
Cat. No.ABIN6559833
Quantity100 tests

We offer custom Made-to-order Proteins

We support you with high-purity made-to-order proteins with native state folding guarantee. Please contact us via email, chat, or phone for more information.

Product
Protein Type
Conjugate
Cat. No.
Quantity
Protein TypeRecombinant
ConjugateHis tag
Cat. No.ABIN3087964
Quantity1 mg
Protein TypeRecombinant
ConjugateHis tag
Cat. No.ABIN3136754
Quantity1 mg
Protein TypeRecombinant
ConjugateHis tag
Cat. No.ABIN3077722
Quantity1 mg
Protein TypeRecombinant
Conjugaterho-1D4 tag
Cat. No.ABIN3092348
Quantity0.5 mg
Protein TypeRecombinant
ConjugateHis tag
Cat. No.ABIN3086478
Quantity1 mg
Protein TypeRecombinant
ConjugateHis tag
Cat. No.ABIN3082621
Quantity1 mg

antibodies-online.com: Making the Complex Convenient

  • Target Coverage: 330 Stargardt Disease-related antibodies, proteins, ELISA kits covering all relevant targets
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References:

  • (1) Tanna P, Strauss RW, Fujinami K, Michaelides M. Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options. Br J Ophthalmol. 2017 Jan;101(1):25-30. doi: 10.1136/bjophthalmol-2016-308823. Epub 2016 Aug 4. PMID: 27491360; PMCID: PMC5256119.
  • (2) Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K. ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet. 2009 Mar 1;18(5):931-41. doi: 10.1093/hmg/ddn421. Epub 2008 Dec 12. PMID: 19074458; PMCID: PMC2640207.
  • (3) Agbaga MP, Tam BM, Wong JS, Yang LL, Anderson RE, Moritz OL. Mutant ELOVL4 that causes autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disks. Invest Ophthalmol Vis Sci. 2014 May 15;55(6):3669-80. doi: 10.1167/iovs.13-13099.
  • (4) Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2366-2387. doi: 10.1167/iovs.16-21162.
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