Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Here the authors show that MAL TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 (show TLR4 Proteins) TIR domains and induce formation of MyD88 (show MYD88 Proteins) assemblies.
MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer.
Results show that MAl protein (show Mall Proteins) binds to and regulates MYD88 (show MYD88 Proteins).
This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas
CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia
Hypermethylation of the selected markers (MAL, PRIMA1 (show PRIMA1 Proteins), PTGDR (show PTGDR Proteins) and SFRP1 (show SFRP1 Proteins)) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL.
The use of CADM1, MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus.
MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells.
MAL hypermethylation is associated with esophageal carcinoma progression.
Expression of the developmentally regulated proteolipid MAL is required for the cytotoxic effect of Clostridium perfringens Epsilon Toxin.
MAL (show TIRAP Proteins) overexpression leads to reduced expression of Mpz and p75NTR (show NGFR Proteins), despite functional pathways and normal expression of genes important for Schwann cell differentiation.
the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
Phagosomal retention of Francisella tularensis results in TIRAP/Mal (show TIRAP Proteins)-independent TLR2 signaling.
The specific reduction and mistargeting of MAL protein (show Mall Proteins) as a reaction to sulfatide overload may contribute to the pathogenic mechanisms in metachromatic leukodystrophy.
Our results demonstrate a critical role for MAL in the maintenance of central nervous system paranodes, likely by controlling the trafficking and/or sorting of NF155 and other membrane components in oligodendrocytes.
Our results suggest a functional role for MAL in peripheral myelination by influencing the expression of membrane components that mediate axon-glia interaction during ensheathment and myelin wrapping.
SYP is an hexameric MAL-domain channel protein.
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.
T-lymphocyte maturation-associated protein
, myelin and lymphocyte protein
, MyD88 adapter-like protein
, Toll-like receptor adaptor protein
, adapter protein wyatt
, adaptor protein Wyatt
, toll/interleukin-1 receptor domain-containing adapter protein
, myelin and lymphocyte protein, T-cell differentiation protein
, Myelin and lymphocyte protein
, 17 kDa myelin vesicular protein
, NS 3
, VIP17 proteolipid
, VIP17/MAL proteolipid
, MAL-like protein