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anti-Human RAB10 Antibodies:
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Human Monoclonal RAB10 Primary Antibody for ICC, ELISA - ABIN969376
Chen, Holcomb, Moore: Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. in Proceedings of the National Academy of Sciences of the United States of America 1993
Show all 3 Pubmed References
Our results suggest that RAB10 could be a promising therapeutic target for Alzheimer's Disease prevention
RAB10 regulates cell survival and proliferation through multiple oncogenic, cell stress and apoptosis pathways. More importantly, high RAB10 expression levels in HCC (show FAM126A Antibodies) cells correlated with a poor prognosis in HCC (show FAM126A Antibodies) patients.
miR (show MLXIP Antibodies)-329 also suppresses wound-healing and migration ability of osteosarcoma cells and inhibits tumorigenicity in vivo. Rab10 was identified as a target of miR (show MLXIP Antibodies)-329 in osteosarcoma and mediates its biofunction
Data suggest that MGCRABGAP (show TBC1D21 Antibodies) is involved in mammalian spermiogenesis by modulating RAB10.
the target gene RAB10 regulated by miRNA-369-3p, miRNA-30e-5p, miRNA-30e-3p, and miRNA-655 may play key role in the progression and development of AD.
The Anaplasma phagocytophilum surface protein, uridine monophosphate kinase (show UCK2 Antibodies), was identified as a guanine nucleotide-independent, Rab10-specific ligand.
Rab10 is a target of the GTPase-activating protein (show RASA1 Antibodies) AS160 (show TBC1D4 Antibodies), which is inhibited after phosphorylation by the protein kinase (show CDK7 Antibodies) Akt (show AKT1 Antibodies).
Rab10 silencing increased the plasma membrane residence of HAS3 (show HAS3 Antibodies), resulting in a significant increase of hyaluronan secretion and an enlarged cell surface HA coat, whereas Rab10 overexpression suppressed hyaluronan synthesis.
Rab10 regulates endoplasmic reticulum dynamics/morphology. Suggest that these dynamics could be coupled to phospholipid synthesis.
Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C
Rab10 plays a role in oligodendrocyte precursor cell maturation.
SEC16A (show INPP5E Antibodies) and RAB10 promote insulin (show INS Antibodies)-stimulated mobilization of GLUT4 (show SLC2A4 Antibodies) from a perinuclear recycling endosome/trans Golgi network compartment.
Glut4 (show SLC2A4 Antibodies) traffics predominantly through the specialized Rab10-dependent pathway both before and after insulin (show INS Antibodies) stimulation.
role of Rab10 in mouse embryo
These results suggest that the association of Rab10-GTP (show AK3 Antibodies) with Exoc6 (show EXOC6 Antibodies)/6b is a molecular link between insulin (show INS Antibodies) signaling and the exocytic machinery in GLUT4 (show SLC2A4 Antibodies) translocation.
RAB10 and its GTPase-activating protein (show RASA1 Antibodies) AS160 (show TBC1D4 Antibodies) comprise the principal signaling module downstream of insulin receptor (show INSR Antibodies) activation that regulates the accumulation of GLUT4 (show SLC2A4 Antibodies) transport vesicles at the plasma membrane.
Rab10 coordinates with myosin-Va (show MYO5A Antibodies) to mediate the final steps of insulin (show INS Antibodies)-stimulated vesicle translocation to the plasma membrane.
show that continuous replenishment of TLR4 (show TLR4 Antibodies) from Golgi to plasma membrane is regulated by the small GTPase (show RACGAP1 Antibodies) Rab10, which is essential for optimal macrophage activation following ipopolysaccharide stimulation.
Rab10 is a target of AS160 (show TBC1D4 Antibodies) and a positive regulator of GLUT4 (show SLC2A4 Antibodies) trafficking to the cell surface upon insulin (show INS Antibodies) stimulation.
Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development.
RAB10 belongs to the RAS (see HRAS\; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998
GTP-binding protein RAB10
, ras-related GTP-binding protein
, ras-related protein Rab-10
, ras-related protein rab10
, rab10 GTP-binding protein
, RAB10, member RAS oncogene family L homeolog
, ras-related GTP-binding protein RAB10