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SH3GLB1 controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5 (show RAB5A ELISA Kits)-dependent manner at steps upstream of autophagosome formation.
These findings thus identify Bif-1 as a novel regulator of lipid homeostasis to prevent the pathogenesis of obesity and its associated metabolic complications.
these data reveal an Irgm1 (show IRGM ELISA Kits)-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy
Our findings suggest that endophilin-B1 is a key mediator of a feed-forward mechanism of Alzheimer's disease pathogenesis
selective autophagy regulates the basal and atrophy-induced turnover of the pentameric transmembrane protein, CHRN, and that TRIM63 (show TRIM63 ELISA Kits), together with SH3GLB1 and SQSTM1 (show SQSTM1 ELISA Kits) regulate this process.
these data suggest that Bif-1 is essential for the maintenance of mitochondrial morphology and function in neurons
Bif-1 haploinsufficiency attenuates mitophagy and results in the promotion of chromosomal instability, which enables tumor cells to efficiently bypass the oncogenic/metabolic pressures for apoptosis.
findings not only establish Cdk5 (show CDK5 ELISA Kits) as a critical regulator of autophagy induction, but also reveal a role for Cdk5 (show CDK5 ELISA Kits) and EndoB1 in the pathophysiology of Parkinson's disease through modulating autophagy
These findings suggest that Bif-1 acts as a critical regulator of Atg9 (show ATG9A ELISA Kits) puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation.
Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax (show BAX ELISA Kits)/Bak (show BAK1 ELISA Kits) activator, and loss of this proapoptotic molecule may contribute to tumorigenesis.
endophilin B1 participates in dynamin 2 (show DNM2 ELISA Kits)-dependent formation of a population of transport vesicles distinct from those generated by A-type endophilins
Bif-1 (show ZBTB24 ELISA Kits) is involved in prostate cancer tumorigenesis and acts as a suppressor in prostate cancer progression.
endophilin B1 mediated the biological function of EGFR (show EGFR ELISA Kits) in cancer cell proliferation through regulating the EGFR (show EGFR ELISA Kits) endocytic trafficking and downstream signaling.
these data reveal an Irgm1 (show IRGM ELISA Kits)-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (show ZBTB24 ELISA Kits)-dependent autophagy
Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5 (show ATG5 ELISA Kits), Ambra1 (show AMBRA1 ELISA Kits), beclin-1 (show BECN1 ELISA Kits), LC3B (show MAP1LC3B ELISA Kits) and Bif-1 (show ZBTB24 ELISA Kits) is significantly correlated with poor outcome.
these data suggest a novel function for Bif-1 (show ZBTB24 ELISA Kits) as a suppressor of breast cancer cell migration by promoting EGFR (show EGFR ELISA Kits) degradation through the regulation of endosome maturation
The expression of Bif-1 (show ZBTB24 ELISA Kits) is downregulated in a subset of pancreatic ductal adenocarcinoma. This novel finding is in agreement with the tumor suppressor function of Bif-1 (show ZBTB24 ELISA Kits).
These findings suggest that Bif-1 (show ZBTB24 ELISA Kits) acts as a critical regulator of Atg9 (show ATG9A ELISA Kits) puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation.
GSK-3beta (show GSK3b ELISA Kits) promotes cell survival by modulating Bif-1 (show ZBTB24 ELISA Kits)-dependent autophagic response and cell death.
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants.
SH3-domain GRB2-like endophilin B1
, SH3 domain-containing GRB2-like protein B1
, Bax-interacting factor 1
, SH3-containing protein SH3GLB1
, protein phosphatase 1, regulatory subunit 70
, SH3-domain GRB2-like B1 (endophilin)
, SH3 domain GRB2-like protein B1