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AFP slope increasing greater than 7.5 ng/mL per month despite locoregional therapy is associated with post-liver transplantation hepatocellular carcinoma recurrence and may serve as a surrogate for microvascular invasion.
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AFP-positivity is a significant negative predictor of overall survival in patients with colorectal cancer, which may be mediated by hepatocyte growth factor / c-Met signaling pathway.
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Peak preoperative serum alpha-fetoprotein to total tumor volume predicts recurrence of hepatocellular carcinoma.
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the results suggest that AFP may positively regulate cell proliferation by enhancing the apoptosis resistance via effect on TGF-beta and p53/Bax/caspase-3 signaling pathway in HepG2 cells. As such, the knockdown of AFP gene should be further investigated in vivo as a novel approach to hepatocellular carcinoma treatment.
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Aberrant CTNNB1 expression was seen in a substantial proportion of our hepatocellular carcinoma (HCC) cases. CTNNB1-positive HCC was associated with normal AFP levels, unicentric tumors, well-differentiated histology, and an unfavorable outcome.
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Elevated preoperative serum alpha-fetoprotein levels have predictive value for hepatocellular carcinoma survival.
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Cases of ovarian ovarian Sertoli-Leydig cell tumors (SLCTs) with elevated serum AFP should be sampled extensively to look for foci of intestinal-type glands, the likely source of the alpha fetoprotein (AFP) elevation in some of these neoplasms.
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In HBV-related cirrhosis, the combination of miR-122, AFP and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
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Examination of AFP over time has great predictive and prognostic value for managing advanced gastric cancer. For those with markedly elevated AFP, triplet regimens may be a better choice.
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Low expression of AFP is associated with recurrence of hepatocellular carcinoma.
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High-levels of PIVKA-II in at-risk patients is an indicator of hepatocellular carcinoma (HCC)development in two-year time. CONCLUSIONS: Our data showed that PIVKA-II effectively increases the detection rate of HCC was a valid complement to AFP and image examination in HCC surveillance
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Unspecific AFP elevations occur in about 2% of pure testicular seminoma patients.
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serum level in the second trimester an important indicator of fetal surface malformations
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HCC [hepatocellular carcinoma] patients who are sero-positive for DCP [Des-gamma-carboxyprothrombin] and sero-negative for AFP[Alpha-fetoprotein] have significantly higher levels of serum ALT[alanine aminotransferase]; serum ALT levels may be of diagnostic importance in AFP-negative, HBV-related HCC [hepatitis B virus-related hepatocellular carcinoma] patients.
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Higher baseline serum AFP levels independently predicted a lower sustained viral response to antivirals among patients with chronic hepatitis C.
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Computer modeling shows the identification of potential binding sites of lysophospholipids (LP) receptors on the AFP third domain receptor binding fragment. AFP might bind not only to the LPL receptors, but also to LPLs themselves since AFP binds medium and long chain fatty acids. It is proposed that some of the activities ascribed to AFP might be due in part to the presence of bound LPLs and/or their receptors. [review]
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AFP may be an important molecule acting against paclitaxel-inhibited proliferation and induced apoptosis in hepatocellular carcinoma cells via repressing the activity of caspase-3 and stimulating the expression of Ras and Survivin.
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PIVKA II, when combined with AFP, may be considered as a screening test for hepatocellular carcinoma due to its high negative predictive value.
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Identification of the distinct impact of circulating tumor derived AFP on NK-cell function and viability may be crucial to developing a strategy to ameliorate hepatocellular carcinoma patient NK-cell functional deficits.
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The detection of ALT, AFP, AFP-L3, and GP73 has a certain guiding significance to predict the risk of hepatocellular carcinoma in hepatic cirrhosis patients
