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anti-Human DRD4 Antibodies:
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Human Monoclonal DRD4 Primary Antibody for WB - ABIN1882235
Zeng, Ye, Lu, Chua, Tan, Zhong: Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes. in Organic letters 2010
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Human Monoclonal DRD4 Primary Antibody for WB - ABIN1882234
Lai, Zhu, Huo, Sun, Yu, Wang, Chai, Li: Association study of polymorphisms in the promoter region of DRD4 with schizophrenia, depression, and heroin addiction. in Brain research 2010
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Human Polyclonal DRD4 Primary Antibody for FACS, IHC (p) - ABIN652706
Ma, Thapa, Morris, Michalakis, Biel, Frank, Bebak, Ding: Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study. in Human molecular genetics 2013
Human Polyclonal DRD4 Primary Antibody for ELISA - ABIN547756
Li, Sham, Owen, He: Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). in Human molecular genetics 2006
Authors examined the possible association between DRD4 allelic variation and three measures of juvenile behavior. Five different DRD4 alleles (5R, 5.5R, 6R, 6.5R, and 7R) were identified in the subject population.
Extrastriatal D2, D3, and D4 receptor activation in external pallidal segments also influences direct pathway elements in the basal ganglia under normal and parkinsonian conditions.
A meta-analysis of DRD4 exon III variable number of tandem repeat (VNTR) and COMT Val158Met association with novelty seeking behavior showed evidence of association between the DRD4 exon III VNTR polymorphism and novelty-seeking, which is inconsistent with the results of previous published meta-analysis.
Mothers who carry the long allele of DRD4 and experienced more adverse life events are less sensitive in interactions with their children.
The presence of the DRD4 7-repeat allele was associated with less disorganized attachment and the effect of the DRD4 genotype may be moderated by infant birth weight and by maternal depression.
genetic association studies in population of young adults in Columbia: Data suggest that genetic polymorphisms in DRD4 and SLC6A3 are associated with overweight/obesity in the population studied; DRD4 4/4 genotype is associated with lower BMI and SLC6A3 10/10 genotype is associated with higher BMI. (DRD4 = dopamine receptor D4; SLC6A3 = solute carrier family 6 member 3)
data imply that enhanced D4 receptor-mediated dopaminergic control of corticostriatal transmission constitutes a vulnerability factor of ADHD and other neuropsychiatric disorders.
These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop.
These results showed that C-allele carriers were associated with a higher erousal from sleep, decreased gray matter volume and functional connectivity density in the pregenual anterior cingulate cortex; children with primary nocturnal enuresis carrying the C allele exhibit decreased gray matter volume and functional connectivity density in the thalamus.
Results suggest that alterations in the glutamate and dopamine system (GRIN2B and DRD4) in attention-deficit/hyperactivity disorder may contribute to abnormalities in local functional connectivity and its dynamic repertoire in the superior parietal area, and these abnormalities would be related to dysfunction in sustained and divided attention.
There is significant interaction effects of the GIT1 and DRD4 gene variants on impulsivity in Attention Deficit Hyperactivity Disorder.
The DRD4 and 5HTR2A genes are co-expressed in Peripheral Blood Mononuclear Cells during antipsychotic administration. Despite a correlation between the studied biogenic amine indicators and the psychopathological status of patients, reliable biomarkers of treatment response could not be determined.
heterozygotes at the DRD4 locus are more risk averse than either homozygotes
We report an interaction between birth weight status and DRD4 gene in predicting respiratory sinus arrhythmia, such that DRD4 long carriers had the highest and lowest resting respiratory sinus arrhythmia depending on whether they were born normal or extremely low birth weight, respectively.
This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents.
DRD4 haplotypes may play a role in general psychopathology in patients with eating disorders
Results indicated that DRD4 L carriers with a sexual trauma history reported significantly more severe suicidal ideation than DRD4S homozygotes.
DRD4 x Positive peer affiliation interaction on the right fusiform gyrus (rFG) activation during successful inhibition.
over-suppression of NMDAR function may underlie the role of hD4.7 in attention deficit hyperactivity disorder
nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls. No significant association was observed.
The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants, DRD$ and DRD2 have been associated with attention difficulties.
Study analyzed the effects of DRD4 and DAT1, prenatal exposure to alcohol and smoking and their interactions on attention-deficit/hyperactivity disorder severity, response inhibition and brain activity; found no significant gene x environment interaction effects.
Results indicate that the full rescue of impaired LTP in aging is achieved by the selective D4R activation.
Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration
The G-protein coupled receptor, DRD4, requires ARR1 and ARR4 for desensitization and internalization.
This study demonstrated that dopamine D4 receptor gene has an important role in increased exploratory and anxiolytic behavior only in males and these behaviors were positively correlated with increased alcohol consumption.
Contrast sensitivity is reduced in Drd4-/- mice.
dopaminergic modulation of early long-term potentiation in stratum oriens occurs through NMDA receptors containing NR2B subunits via D4Rs
Data demonstrate that stimulating the dopamine Dreceptor is essential in maintaining the normal rhythmic production of adenylyl cyclase 1 from transcript to enzyme activity.
This study demonistrated that the dopamine D4 receptor is the role of attention.
The result of this study demonistrated that the dopamine drd4 receptor appears to be important for specific exploration.
Data suggest that dopamine D4 receptors modulate not only the prefrontal cortex, but also the cerebellar vermis, which may reflect an indirect modulation as D4Rs are minimally expressed in this region.
no connection between analysed polymorphism of genes: DRD2, DRD3, DRD4, DAT, COMT and schizophrenia was stated.
This result suggests an effect of 5-HTTLPR on externalizing behavior in the presence of DRD4 7r but no effect in its absence.
absence of D4Rs increases avoidance behaviour to unconditioned stimuli and does not impair behavioural reactions to Pavlovian fear-conditioning
Postsynaptic activation of dopamine D4 receptors reduces GABAergic currents in globus pallidus neurons.
D4R signaling is essential for the expression of juvenile hyperactivity and impaired behavioral inhibition, relevant features present in this attention deficit disorder-like mouse model.
The findings suggest that D1, D4, and NMDA receptors may interact functionally and that developmental absence of D4 receptors might trigger compensatory mechanisms that enhance expression of D1 receptors
D4 dopamine receptor is found to be expressed in the subcommissural organ (SCO), an ependymal brain gland that is located in the roof of the third ventricle.
Absence of dopamine D4 receptor increases blood pressure, possibly via increased angiotensin II type 1 receptor expression.
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats\; the sequence shown contains four repeats.
dopamine D4b receptor
, dopamine receptor D4
, D(2C) dopamine receptor
, D(4) dopamine receptor
, dopamine D4 receptor
, seven transmembrane helix receptor
, d(2C) dopamine receptor
, dopamine receptor 4