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Human Polyclonal EGLN1 Primary Antibody for FACS, ICC - ABIN151071
Elvidge, Glenny, Appelhoff, Ratcliffe, Ragoussis, Gleadle: Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. in The Journal of biological chemistry 2006
Show all 66 Pubmed References
Human Polyclonal EGLN1 Primary Antibody for ICC, IF - ABIN250635
Mikhaylova, Ignacak, Barankiewicz, Harbaugh, Yi, Maxwell, Schneider, Van Geyte, Carmeliet, Revelo, Wyder, Greis, Meller, Czyzyk-Krzeska: The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. in Molecular and cellular biology 2008
Show all 24 Pubmed References
Human Polyclonal EGLN1 Primary Antibody for EM, FACS - ABIN151072
Baek, Mahon, Oh, Kelly, Krishnamachary, Pearson, Chan, Giaccia, Semenza: OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. in Molecular cell 2005
Show all 16 Pubmed References
Human Monoclonal EGLN1 Primary Antibody for IHC, IHC (p) - ABIN440716
Stolze, Tian, Appelhoff, Turley, Wykoff, Gleadle, Ratcliffe: Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. in The Journal of biological chemistry 2004
Show all 4 Pubmed References
Human Polyclonal EGLN1 Primary Antibody for ELISA, WB - ABIN565755
Aprelikova, Pandolfi, Tackett, Ferreira, Salnikow, Ward, Risinger, Barrett, Niederhuber: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. in Cancer research 2009
oxygen via Phd2 has a decisive influence on the formation of the vascular network during vertebrate embryogenesis.
comparative analysis of phd1 (show EGLN2 Antibodies), 2, and 3 expression in Xenopus laevis
the expression of PHD2 in endothelial cells plays a critical role in renal fibrosis and vascular remodelling in adult mice.
Phd2 expressed in chondrocytes inhibits endochondral ossification at the epiphysis by suppressing HIF signaling pathways.
brain tissue protection and increased angiogenesis upon sub-acute ischemic stroke was completely absent in Phd2 knockout mice that were additionally deficient for both Hif1a (show HIF1A Antibodies) and Hif2a (show EPAS1 Antibodies)
expression of PHD2 in endothelial cells plays a critical role in preventing pulmonary arterial remodeling in mice
PHD-2 knockdown mesenchymal stromal cells overexpressed HIF-1alpha (show HIF1A Antibodies) and multiple angiogenic factors compared to control. Wounds treated with PHD-2 knockdown mesenchymal stromal cells healed at a significantly accelerated rate compared with wounds treated with shScramble mesenchymal stromal cells.
data identify the PHD2:HIF-2alpha:EPO axis as a so far unknown regulator of osteohematology by controlling bone homeostasis.
miR (show MLXIP Antibodies)-21 contributes to the protection of delayed ischemic preconditioning against renal ischemia reperfusion injury in mice, which is at least in part mediated by targeting of PHD2 and subsequently up-regulating HIF-1alpha (show HIF1A Antibodies)/VEGF (show VEGFA Antibodies) pathway.
Phd2 is the dominant HIF-hydroxylase in neutrophils under normoxic conditions; intrinsic regulation of glycolysis and glycogen (show GYS1 Antibodies) stores is linked to the resolution of neutrophil-mediated inflammatory responses
Epo (show EPO Antibodies) transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 and PHD3 (show EGLN3 Antibodies), oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.
Notch ligand (show JAG2 Antibodies) genes Jag1 (show JAG1 Antibodies), Jag2 (show JAG2 Antibodies), and Dll1 (show DLL1 Antibodies) and target Hes1 (show HES1 Antibodies) became downregulated upon aging HIF-2alpha (show EPAS1 Antibodies) dependently.
GPT2 (show GPT2 Antibodies) reduced alpha-ketoglutarate level in cells leading to the inhibition of proline hydroxylase 2 (PHD2) activity involved in the regulation of HIF1alpha (show HIF1A Antibodies) stability. Accumulation of HIF1alpha (show HIF1A Antibodies), resulting from GPT2 (show GPT2 Antibodies)-alpha-ketoglutarate-PHD2 axis, constitutively activates sonic hedgehog (Shh (show SHH Antibodies)) signaling pathway.
Studied the association between SNPs around the EGLN1 genomic region, possibly involved in high-altitude adaptation, and physiological changes to hypobaric hypoxia exposure in a cohort of Japanese lowlanders.
the expression of prolyl hydroxylase domain 2 (PHD2) is selectively increased in CKD-AT-MSCs and its inhibition can restore the expression of HIF-1alpha (show HIF1A Antibodies) and the wound healing function of CKD-AT-MSCs. These results indicate that more studies about the functions of MSCs from CKD patients are required before they can be applied in the clinical setting
Functionally active PHD2 SNP rs516651 , located in the key pathway for the hypoxic-inflammatory response, is associated with increased 30-day mortality in Acute Respiratory Distress Syndrome (ARDS) patients. In contrast, the PHD2 SNP rs480902 is not. Furthermore, the HIF-2alpha (show EPAS1 Antibodies) SNP [ch2 (show Acyp1 Antibodies): 46441523(hg18)] GG-genotype was neither present in our ARDS patients of Caucasian heritage nor in healthy Caucasian blood donors.
We genotyped 347 Tibetan individuals from varying altitudes for both the Tibetan-specific EGLN1 haplotype and 10 candidate SNPs in the EPAS1 haplotype and correlated their association with hemoglobin levels.
PHD2 is a direct binding partner of EGFR (show EGFR Antibodies) and show that PHD2 regulates EGFR (show EGFR Antibodies) stability as well as its subsequent signaling in breast carcinoma cells.
A mechanism of PHD2 regulation that involves the mTOR (show FRAP1 Antibodies) and PP2A (show PPP2R4 Antibodies) pathways.
These data unravel B55alpha (show PPP2R2A Antibodies) as a PHD2 substrate and highlight a role for PHD2-B55alpha (show PPP2R2A Antibodies) in the response to nutrient deprivation.
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
egl nine homolog 1 (C. elegans)
, egl nine homolog 1
, egl nine homolog 1-like
, egl nine homolog 2
, HIF-prolyl hydroxylase 2
, hypoxia-inducible factor prolyl hydroxylase 2
, prolyl hydroxylase domain-containing protein 2
, HIF prolyl hydroxylase 2
, egl nine-like protein 1
, zinc finger MYND domain-containing protein 6