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Mouse (Murine) Polyclonal Endothelin-1 Receptor Primary Antibody for ICC, IF - ABIN269861
Meehan, Delimont, Dufek, Zallocchi, Phillips, Gratton, Cosgrove: Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice. in Hearing research 2016
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Chicken Polyclonal Endothelin-1 Receptor Primary Antibody for IHC (p), IHC - ABIN443474
Cook, Brais, Qian, Hak, Corrie: Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma. in Journal of clinical pathology 2015
Show all 2 Pubmed References
Presence of SST5 (show SSTR5 Antibodies), CXCR4 (show CXCR4 Antibodies) and ETA on tumor cells and of SST3, CXCR4 (show CXCR4 Antibodies) and ETA on microvessels gradually increased from grade II to grade IV tumors.
There is no association between the C+70G polymorphism of the EDNRA gene and the development of ischemic atherothrombotic stroke.
endothelin-A receptor-activated ABCB1 (show ABCB1 Antibodies) expression has a role in nintedanib resistance in FGFR1 (show FGFR1 Antibodies)-driven small cell lung cancer
Endothelin-1 (show EDN1 Antibodies) possesses an anti-apoptotic effect in vascular endothelial cells and this effect is mediated, to a great extent, via the activation of EDNRB (show EDNRB Antibodies), with a minor contribution via activation of EDNRA.
Polymorphic variants of endothelin EDN (show RNASE2 Antibodies) (K198N) and endothelin receptor type A genes EDN (show RNASE2 Antibodies) RA (C1222T, C70G, G231A) affected ET plasma concentrations. There was no association between the plasma endothelin levels and the risk factors for normal tension glaucoma.
ETA and ETB (show EDNRB Antibodies) receptors are present in human haemorrhoids with ETB (show EDNRB Antibodies) receptors predominating
ETAR stimulation acted via downstream G-protein Galphaq (show GNAQ Antibodies)/11 and Rho GTPase (show RACGAP1 Antibodies) to suppress the Hippo pathway, thus leading to YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) activation, which was required for ETAR-induced tumorigenesis. Overall, these results indicate a critical role of the YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) axis in ETAR signaling
Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (show ARRB1 Antibodies) (beta-arr1 (show ARRB1 Antibodies)) with Rho guanine nucleotide exchange factor (GEF) 11 (show ARHGEF11 Antibodies) protein (PDZ-RhoGEF (show ARHGEF11 Antibodies)).
In control arteries, ETAR was expressed by vascular smooth muscle cells in the media whereas ETBR (show EDNRB Antibodies) was hardly detected. In giant cell arteritis, both ETAR and ETBR (show EDNRB Antibodies) receptors were expressed by alphaSMA (show ACTA2 Antibodies)-positive cells at the intima-media border. Endothelial cells and inflammatory cells also expressed both ET receptors.
Increased circulating Edn1 (show EDN1 Antibodies) and expression of Ednra in endothelial cells are characteristic of diabetic kidney disease.
Mutant Ednra (Y129F) mice represent a valuable viable model for complex human syndromes of the first and second pharyngeal arches and for further studies and analysis of impaired endothelin 1 (EDN1 (show EDN1 Antibodies))-endothelin receptor type A (EDNRA) signaling. Above all, Ednra (Y129F) mice model the recently published human MFDA syndrome and may be helpful for further disease understanding and development of therapeutic interventions
endothelin A receptor activation on mesangial cells is a key event in initiation of Alport glomerular disease in this mouse model.
Increased circulating Edn1 (show EDN1 Antibodies) and expression of Ednra in endothelial cells are characteristic of diabetic kidney disease-susceptible mice.
Atrasentan treatment was effective in reducing the severity of colitis in DSS (show PMP22 Antibodies)- and TNBS-treated mice, suggesting that ETA receptors might be a potential target for inflammatory bowel diseases
Endothelin A receptor may be involved in paraquat-induced toxic myocardial contractile anomalies possibly related to apoptosis and mitochondrial damage.
ETAR-positive macrophages highly accumulated in the inflamed liver of mutant p53 (show TP53 Antibodies)(R172) plus IL27RA (show IL27RA Antibodies)(-/-)
these results indicated that I/R induced upregulation of ET1 (show EDN1 Antibodies) and ETA in the kidneys, which was, at least in part, dependent on the production of inflammatory cytokines.
The cardiac expression of prepro-endothelin-1 (show EDN1 Antibodies) mRNA, endothelin-converting enzyme-1 (show ECEL1 Antibodies) mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight
Venous Edn1 (show EDN1 Antibodies) guides stellate ganglia axons to innervate the developing heart via Ednra on those axons. Edn1 (show EDN1 Antibodies)-Ednra signalling is essential for functional regulation of the heart by sympathetic nerves.
ednra expression within the heart was restricted to the myocardium
Data suggest that edn1 (show EDN1 Antibodies)/ednraa (endothelin-1/endothelin-1 (show EDN1 Antibodies) receptor type A) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase (show DNAH8 Antibodies) in zebrafish embryonic skin.
Edn1 (show EDN1 Antibodies) from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
Data suggest that, in Fallopian tubes, endothelins (EDN1 (show EDN1 Antibodies), EDN2 (show EDN2 Antibodies), EDN3 (show EDN3 Antibodies)) and EDN (show RNASE2 Antibodies)-converting enzymes (ECE1 (show ECE1 Antibodies), ECE2 (show ECE2 Antibodies)) are expressed in epithelial cells; EDN (show RNASE2 Antibodies) receptors (EDNRA, EDNRB (show EDNRB Antibodies)) are present in smooth-muscle. Expression of EDN1 (show EDN1 Antibodies), EDN2 (show EDN2 Antibodies), and ECE2 (show ECE2 Antibodies) is highest on day of ovulation. EDN (show RNASE2 Antibodies)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
Differential cell-specific and spatiotemporal expression of the EDN1 (show EDN1 Antibodies) system and NOS (show NOS Antibodies) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Elevated local expression of ET-1 (show EDN1 Antibodies) and Ednra/Ednrb (show EDNRB Antibodies) during the peri (show PLIN1 Antibodies)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
A new role for ednra signaling during early neural crest specification is reported.
sub-vasomotor concentration of ET-1 (show EDN1 Antibodies) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Antibodies) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Antibodies) following ETA receptor activation
PDE5 (show PDE5A Antibodies) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB (show EDNRB Antibodies) receptor blockade in the presence of PDE5 (show PDE5A Antibodies) inhibition.
Blocking ET(A) and ET(B (show EDNRB Antibodies)) receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high intra-abdominal pressure (IAP (show CD47 Antibodies)).
Anti-endothelin receptor A therapy accelerated the reversal of flow-induced pulmonary arterial disease after flow correction.
study suggests a possible role for endothelin-1 (show EDN1 Antibodies)(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Antibodies)) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig
Endothelin-A receptor antagonist alters the expression of vasoactive genes and proinflammatory cytokines during hepatic ischemic/reperfusion.
Report that inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury improved gas exchange and hemodynamics.
ET(A) blockade had no effect on pulmonary vascular resistance at rest or during exercise.
PKC (show FYN Antibodies) and MAPK (show MAPK1 Antibodies) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries
Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR antagonists might be beneficial for treatment of laminitis in horses.
both endothelin A and endothelin B receptors are involved in the net tonic response to ET-1 (show EDN1 Antibodies) in normal laminar veins.
Stimulation of ETA and ETB receptors activates native protein kinase C-dependent transient receptor potential channel (TRPC)1 through phospholipid pathways involving phosphoinositol-3,4,5-trisphosphate (PIP)3 and PIP2 in coronary artery myocytes.
ETRA is expressed distinctly in the brain tissue, and it may play an important role in delayed neurological deficit pathogenesis.
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
G protein-coupled receptor
, endothelin receptor subtype A
, endothelin-1 receptor
, endothelin-1-specific receptor
, endothelin A receptor
, G-protein coupled receptor 10
, endothelin receptor A
, endothelin receptor type A
, endothelin type-A receptor 2
, Endothelin-1 receptor type A
, endothelin receptor type A a
, LOW QUALITY PROTEIN: endothelin-1 receptor