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Human GNB2L1 Protein expressed in Wheat germ - ABIN1355363
Lacombe, Mangé, Jarlier, Bascoul-Mollevi, Rouanet, Lamy, Maudelonde, Solassol: Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers. in International journal of cancer. Journal international du cancer 2013
Show all 2 Pubmed References
RACK1 emerges as an important marker of malignancy which may contribute to progress in the diagnosis of melanomas in both human and veterinary medicine.[RACK1]
The data of this study suggested that point contacts are a targeted site of local translation within growth cones, and RACK1 is a critical member of the point contact complex and necessary for appropriate neural development.
A sequential and coordinated activation of ERK (show EPHB2 Proteins), JNK (show MAPK8 Proteins) and STAT3 (show STAT3 Proteins) with RACK1 is shown to accelerate aggressive melanoma development in vivo.
Leads to the enhanced and previously un-described interaction of RACK1 and TCTP (show TPT1 Proteins).
urther investigation indicated that p205 may disturb the formation of Runx2 (show RUNX2 Proteins)/Ids (show IDS Proteins) complex and free more Runx2 (show RUNX2 Proteins) to induce the differentiation process. Taken together, our findings demonstrated for the first time that p205 functions as an activator in osteoblast differentiation.
RACK1 competes with Rab40C (show RAB40C Proteins) for binding to the ANKR2 domain of Varp (show ANKRD27 Proteins) and regulates dendrite outgrowth through stabilization of Varp (show ANKRD27 Proteins) in mouse melanocytes
Data show that receptor for activated C-kinase 1 (RACK1) and vascular endothelial growth factor (VEGF (show VEGF Proteins)) expression is up-regulated after choroidal neovascularization (CNV) formation.
RACK1 is a novel factor required for adipocyte differentiation.
deficit of RACK1 in hippocampus impairs the ability of learning and memory in mice via up regulating autophagy
RACK1 plays an important role in the maintenance of morphine conditioned place preference, likely via activation of ERK (show EPHB2 Proteins)-CREB (show CREB1 Proteins) pathway in hippocampus.
Thr50 phosphorylation of RACK1 enhances its direct binding to Vps15, Atg14L, and Beclin 1 (show BECN1 Proteins), thereby promoting the assembly of the autophagy-initiation complex.
Data indicate that RACK1 increases interactions between Akt (show AKT1 Proteins) and MCM7 (show MCM7 Proteins) and promotes Akt (show AKT1 Proteins)-dependent MCM7 (show MCM7 Proteins) phosphorylation, which in turn increases MCM7 (show MCM7 Proteins) binding to chromatin and miniature chromosome maintenance (MCM) complex formation.
the depletion of ribosomal RACK1 alters the capacity of the ribosome to translate specific mRNAs, resulting in selective translation of mRNAs of genes for non-canonical autophagy induction.
This work has significantly advanced our understanding of the RACK1/PP2A (show PPP2R4 Proteins) complex and suggests a pro-carcinogenic role for the RACK1/PP2A (show PPP2R4 Proteins) interaction. This work suggests that approaches to target the RACK1/PP2A (show PPP2R4 Proteins) complex are a viable option to regulate PP2A (show PPP2R4 Proteins) activity and identifies a novel potential therapeutic target in the treatment of breast cancer.
Our analysis shows that most of the interaction partners with putative regulatory functions have binding sites that are available on ribosomal RACK1, supporting the role of RACK1 as a ribosomal signaling hub.
This supports PDE4D5 and RACK1 as potential regulators of cell adhesion, spreading and migration through the non-classical exchange protein activated by cyclic AMP (EPAC1)/Rap1 signalling route
In this review we summarize this evidence and examine the mechanisms that underlie the contribution of RACK1 to the various stages of cell migration and invasion.
Analysis of deletion constructs of SERBP1 (show SERBP1 Proteins) showed that the C-terminal third of the SERBP1 (show SERBP1 Proteins) protein, which contains one of its two substrate sites for protein arginine N-methyltransferase 1 (PRMT1 (show PRMT1 Proteins)), is necessary and sufficient for it to interact with RACK1
identification of regulatory elements in the promoter of RACK1 shed some light on its transcriptional modulation in physiological and pathological context.These and other informations suggest that a better understanding of RACK1 transcriptional regulation is essential to unravel its role.
Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2 (show PDLIM2 Proteins), MACC1 (show MACC1 Proteins), NTN4, and GNB2L1.
High RACK1 expression is associated with imatinib resistance in gastrointestinal stromal tumor.
Rack1 has a dominant-negative effect on Vangl2 (show VANGL2 Proteins) localization and gastrulation.
These results suggest that PKCepsilon (show PRKCE Proteins) signaling in the basal airway cell may involve RACK1; however, PKCepsilon (show PRKCE Proteins) regulation in ciliated cells uses RACK1-independent pathways.
this study unveils novel defense mechanisms exist for C. elegans in facilitating enhanced immunity by RACK-1 against Shigella flexneri infection
Lactobacillus casei pretreatment triggers the TLR mediated and rack-1 dependent p38 MAPK (show MAPK14 Proteins) signaling pathway in nematodes. rack-1 is necessary in activating the p38 MAPK (show MAPK14 Proteins) pathway by Lactobacillus casei.
RACK-1 controls the biogenesis of a subset of miRNAs, including let-7, and in this way plays a role in the heterochronic gene pathway during C. elegans development.
RACK1 can contribute to the recruitment of miRISC to the site of translation, and support a post-initiation mode of miRNA-mediated gene repression.
show that depletion of Caenorhabditis elegans RACK-1, which leads to short astral microtubules during prometaphase, specifically affects maintenance of cortical PAR (show AFG3L2 Proteins) domains and Dynamin localization
These studies pinpoint RACK-1 as a component of a novel signaling pathway involving Rac (show AKT1 Proteins) GTPases and UNC-115/abLIM (show ABLIM1 Proteins).
suggest a mechanism by which RACK-1 directs the dynactin (show DCTN1 Proteins)-dependent redistribution of recycling endosomes during the cell cycle
may act as a receptor for activated protein kinase C
guanine nucleotide binding protein, beta 2, related sequence 1
, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
, G-beta-like protein
, guanine nucleotide-binding protein beta subunit
, activated protein kinase C receptor
, guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1
, guanine nucleotide binding protein related
, guanine nucleotide binding protein, beta-2, related sequence 1
, guanine nucleotide-binding protein subunit beta-2-like 1
, receptor for activated C kinase
, receptor of activated protein kinase C 1
, guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1
, guanine nucleotide binding protein, beta polypeptide 2-like 1
, protein kinase C receptor
, receptor for activated protein kinase C
, cell proliferation-inducing gene 21 protein
, guanine nucleotide-binding protein subunit beta-like protein 12.3
, human lung cancer oncogene 7 protein
, lung cancer oncogene 7
, proliferation-inducing gene 21
, protein homologous to chicken B complex protein, guanine nucleotide binding
, receptor for activated C kinase 1
, receptor of activated protein kinase C
, Guanine nucleotide-binding protein beta subunit2-like 1
, MHC B complex protein 12.3
, guanine nucleotide binding 12.3
, guanine nucleotide-binding protein beta subunit 2-like 1
, G-beta like protein