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anti-Human NPR3 Antibodies:
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The levels of ANP, NPRA, IL-4 and GATA3 increased in peripheral blood of children with respiratory syncytial virus bronchiolitis.
loss of NPR-C reduces HRV due to perturbations in the regulation of the heart by the autonomic nervous system
It was the aim to investigate the expression of natriuretic peptide receptors NPR-A, NPR-B and NPR-C during adipocyte differentiation (AD), upon stimulation with fatty acids (FA), and in murine and human adipose tissue depots.
study identifies novel, putative mechanisms for BP-associated variants at the NPR3 locus to elevate blood pressure.
Suggest that pro-ANP/corin/NPR-C signaling is dominant in the vascular system in preeclampsia.
NPR3 expression is downregulated by MRCCAT1 in the in metastatic clear cell renal cell carcinoma.
This study suggested that NPR3 rs2270915 polymorphism was associated with decreased systolic blood pressure level marginally in essential hypertension patients in a Chinese Han population; the polymorphism may function through decreasing NPR3 mRNA expression and ANP level.
NPR-C gene single nucleotide polymorphisms significantly contribute to CAD susceptibility in the Chinese Han population
The NPRC genetic variant,Rs1847018, is a genetic marker of essential hypertension.
This study focused on the natriuretic peptide receptor C gene (NPR3). The correlation analysis between NPR3 and hypertension was replicated in 450 Chinese Dai and 484 Chinese Mongolian individuals.
Angiotensin II downregulates vascular smooth muscle cell NPR-C gene expression by destabilizing its mRNA.
Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease.
Data show that natriuretic peptide receptor 3 (NPR3) single nucleotide polymorphism (SNP) is independently associated with diastolic dysfunction and does not appear to be related to alterations in circulating levels of natriuretic peptides.
The significant change in NPR3 protein was observed for the Arg146 variant allozyme, with 20% of wild-type protein, primarily because of autophagy-dependent degradation.
polymorphisms or haplotype in NPR3 gene may influence the risk of ischemic stroke or hypertension independently in Chinese population.
a NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility
Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery, with increased expression of NPR3 in histologically unstable plaques.
Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury.
Data found a consistent and significant association between the rs2270915 polymorphism of the NPR3 gene and SBP in diabetic patients. This genetic variation may affect pressure response to changes in dietary sodium.
integrative genomics approach to a large cohort of medulloblastomas has identified four disparate subgroups (NPR3)with distinct demographics, clinical presentation, transcriptional profiles, genetic abnormalities, and clinical outcome.
Study identified 2 versions of the npr1 gene (npr1a and npr1b); npr1a was mainly expressed in tectal ventricle, brian, heart and retina, whereas npr1b was broadly present in anterior pronephric duct. npr2 mainly expressed in branchial arches and neural tube during embryonic development; npr3 was expressed in pronephric ducts and corpuscle of stannius in zebrafish embryos at 72 hours after fertilization.
both NPR1 and NPR3/NPR4 are bona fide salicylic acid receptors, but play opposite roles in transcriptional regulation of salicylic acid-induced defense gene expression
Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway
NPR3 expression was strongest in the petals and sepals of developing flowers and declined after flower opening.
the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind salicylic acid with different affinities
NPR3 and NPR4 negatively regulate PR gene expression and pathogen resistance through their association with TGA2 and its paralogs.[NPR3]
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
atrial natriuretic peptide clearance receptor
, atrial natriuretic peptide receptor 3
, atrial natriuretic peptide receptor type C
, Atrial natriuretic peptide clearance receptor
, natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
, natriuretic peptide receptor type C