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anti-Human SSTR4 Antibodies:
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Human Monoclonal SSTR4 Primary Antibody for IHC (p) - ABIN2476551
Schmid, Lambertini, van Vugt, Barzaghi-Rinaudo, Schäfer, Hillenbrand, Sailer, Kaufmann, Nuciforo: Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors. in Neuroendocrinology 2012
Human Polyclonal SSTR4 Primary Antibody for FACS, ICC - ABIN4355143
Arne, Nilsson, Dalmo, Kristiansson, Arvidsson, Forssell-Aronsson, Nilsson, Ahlman: Gastrointestinal stromal tumors (GISTs) express somatostatin receptors and bind radiolabeled somatostatin analogs. in Acta oncologica (Stockholm, Sweden) 2013
Data showed that the distribution of somatostatin receptor (SSTR) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (54.8%), SSTR1 (53.3%), SSTR4 (51.8%), SSTR5 (33.7%), and SSTR3 (28.6%).
An immunohistochemical investigation of the expression of somatostatin receptor subtypes
deregulated somatostatin signaling in the Alzheimer disease cortices studied cannot be explained by hypermethylation of the SST or SSTR4 promoter CpG islands.
this study shows that CD26 is associated with SSTR4 in malignant pleural mesothelioma cells, and this interaction inhibits SSTR4-mediated cytostatic effects.
High SSTR4 expression is associated with lymph node metastasis in gallbladder cancer.
Data show that the mRNA levels of SSTR1, SSTR2, SSTR3, and SSTR5 were high in PET compared with AC, whereas the expression of SSTR4 was low in PET and AC.
Studies show that this study may be the basis for further functional studies to evaluate the role of somatostatin receptors sst1 to sst5 in the diabetic state.
Evaluation of the potential use of sst5TMD4 expression in surgically removed pituitary adenomas as a predictor of the subsequent response of different pituitary tumors to somatostatin therapy.
In somatotrophinomas patients treated with somatostatin analogs, the most expressed SSTR was SSTR5, SSTR3, SSTR2, SSTR1, and SSTR4, respectively.
SSTR transcripts are expressed and functional in retroorbital fibroblasts. SSTR1 is expressed in Grave's disease and octreotide inhibits retroorbital cell growth, explaining the SRIH therapeutic effect.
SSTRs 1-5 are heterogeneously expressed in gastroenteropancreatic endocrine tumors
expression of SSTR4 transcripts up-regulated in prostatic carcinoma cells; SSTR4 agonists may have role in treatment of prostate cancer
somatostatin receptor transcripts were found in lymphocytes both from Graves' ophthalmopathy retroorbital tissues and blood samples, with levels of expression of SST1, -2, and -4 mRNA higher than those of the SST3 and -5 transcripts
A variable degree of SSTR4 was detected in laryngeal benign, premalignant and malignant specimens, with the greatest percentage in teh malignant specimens.
Immunohistochemistry stufy of SSTR4 in prostate tissue from patients with bladder outlet obstruction showed that close to 90% of secretory cells showed a weak positivity in the cytoplasm.
Heterodimerization between somatostatin receptor 4 and somatostatin receptor 5 exerted receptor and ligand specific changes in receptor coupling to adenylyl cyclase and the downstream signaling pathway.
the expression, localization, and inflammation-induced alterations of sst(4) receptors in murine and human lungs
Both hippocampal sst2 and sst4 receptors selectively inhibit stress-induced HPA axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms.
Study provides first evidence that somatostatin 4 receptor activation is involved in the behavioral and neuroendocrine alterations induced by chronic stress with a crucial role of plastic changes in the amygdala.
The results of this study revealed that sst4 mediates anxiolytic and antidepressant-like effects by enhancing the stress-responsiveness of several brain regions with special emphasis on the amygdala.
The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
SSTR4 and delta-Opioid receptor (dOR) exist in a heteromeric complex and function in synergistic manner.
SSTR4-like immunoreactivity increases in ApoD(-/) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
SSTR4 ablation has an effect on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine
sst(2a) and sst(4) were respectively detected in the dentate gyrus (DG) and the CA1 subfield suggesting that their functional interactions are not mediated by direct receptor coupling
The effect of sst2 receptor knockout on sst4 receptor mRNA localization and binding sites throughout the brain has been determined.
Brain somatostatin receptors 1,2,4 and 5 are up-regulated in somatostatin-deficient mice, and SSTR3 is down-regulated.
Expression of SSTR3, SSTR4, and SSTR5 in mouse proximal tubules complements the expression of SSTR1 and SSTR2 in collecting ducts as seen in other species.
Somatostatin sst(4) receptor-selective agonists could be potential candidates for the development of a completely novel group of anti-inflammatory drugs for the treatment of airway inflammation and hyperresponsiveness.
Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.
during the inflammatory conditions the released somatostatin has pronounced counterregulatory effects through sst(4) receptor activation.
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.
somatostatin receptor type 4
, somatostatin receptor 4
, G-protein coupled receptor
, Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA