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anti-Human SSTR4 Antibodies:
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Human Monoclonal SSTR4 Primary Antibody for IHC (p) - ABIN2476551
Schmid, Lambertini, van Vugt, Barzaghi-Rinaudo, Schäfer, Hillenbrand, Sailer, Kaufmann, Nuciforo: Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors. in Neuroendocrinology 2012
Human Polyclonal SSTR4 Primary Antibody for FACS, ICC - ABIN4355143
Arne, Nilsson, Dalmo, Kristiansson, Arvidsson, Forssell-Aronsson, Nilsson, Ahlman: Gastrointestinal stromal tumors (GISTs) express somatostatin receptors and bind radiolabeled somatostatin analogs. in Acta oncologica (Stockholm, Sweden) 2013
Data showed that the distribution of somatostatin (show SST Antibodies) receptor (SSTR (show SSTR3 Antibodies)) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (show SSTR2 Antibodies) (54.8%), SSTR1 (show SSTR1 Antibodies) (53.3%), SSTR4 (51.8%), SSTR5 (show SSTR5 Antibodies) (33.7%), and SSTR3 (show SSTR3 Antibodies) (28.6%).
An immunohistochemical investigation of the expression of somatostatin (show SST Antibodies) receptor subtypes
deregulated somatostatin (show SST Antibodies) signaling in the Alzheimer disease cortices studied cannot be explained by hypermethylation of the SST (show SST Antibodies) or SSTR4 promoter CpG islands.
this study shows that CD26 (show DPP4 Antibodies) is associated with SSTR4 in malignant pleural mesothelioma cells, and this interaction inhibits SSTR4-mediated cytostatic effects.
High SSTR4 expression is associated with lymph node metastasis in gallbladder cancer.
Data show that the mRNA levels of SSTR1 (show SSTR1 Antibodies), SSTR2 (show SSTR2 Antibodies), SSTR3 (show SSTR3 Antibodies), and SSTR5 (show SSTR5 Antibodies) were high in PET compared with AC, whereas the expression of SSTR4 was low in PET and AC.
Studies show that this study may be the basis for further functional studies to evaluate the role of somatostatin (show SST Antibodies) receptors sst1 (show SSTR1 Antibodies) to sst5 (show SSTR5 Antibodies) in the diabetic state.
Evaluation of the potential use of sst5TMD4 expression in surgically removed pituitary adenomas as a predictor of the subsequent response of different pituitary tumors to somatostatin (show SST Antibodies) therapy.
In somatotrophinomas patients treated with somatostatin (show SST Antibodies) analogs, the most expressed SSTR (show SSTR3 Antibodies) was SSTR5 (show SSTR5 Antibodies), SSTR3 (show SSTR3 Antibodies), SSTR2 (show SSTR2 Antibodies), SSTR1 (show SSTR1 Antibodies), and SSTR4, respectively.
SSTR (show SSTR3 Antibodies) transcripts are expressed and functional in retroorbital fibroblasts. SSTR1 (show SSTR1 Antibodies) is expressed in Grave's disease and octreotide inhibits retroorbital cell growth, explaining the SRIH therapeutic effect.
Both hippocampal sst2 (show SSTR2 Antibodies) and sst4 receptors selectively inhibit stress-induced HPA (show HPSE Antibodies) axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms.
Study provides first evidence that somatostatin (show SST Antibodies) 4 receptor activation is involved in the behavioral and neuroendocrine alterations induced by chronic stress with a crucial role of plastic changes in the amygdala.
The results of this study revealed that sst4 mediates anxiolytic and antidepressant-like effects by enhancing the stress-responsiveness of several brain regions with special emphasis on the amygdala.
The expression and localization of the three receptors (SSTR3 (show SSTR3 Antibodies)-SSTR5 (show SSTR5 Antibodies)) in wild-type (WT), single-knockout (SSTR1 (show SSTR1 Antibodies) KO) and double-knockout SSTR1 (show SSTR1 Antibodies)/SSTR2 (show SSTR2 Antibodies) (DKO) mice, are reported.
SSTR4 and delta-Opioid receptor (dOR) exist in a heteromeric complex and function in synergistic manner.
SSTR4-like immunoreactivity increases in ApoD (show APOD Antibodies)(-/) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
SSTR4 ablation has an effect on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine
sst (show SST Antibodies)(2a) and sst(4 (show KIRREL3 Antibodies)) were respectively detected in the dentate gyrus (DG) and the CA1 (show CA1 Antibodies) subfield suggesting that their functional interactions are not mediated by direct receptor coupling
The effect of sst2 (show SSTR2 Antibodies) receptor knockout on sst4 receptor mRNA localization and binding sites throughout the brain has been determined.
Brain somatostatin (show SST Antibodies) receptors 1,2,4 and 5 are up-regulated in somatostatin (show SST Antibodies)-deficient mice, and SSTR3 (show SSTR3 Antibodies) is down-regulated.
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.
somatostatin receptor type 4
, somatostatin receptor 4
, G-protein coupled receptor
, Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA