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The ARL15 and HLA-DMA gene polymorphisms are associated with RA risk in Northwestern Han Chinese population.
pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.
study therefore reveals that HLA-DM polymorphic residues have a considerable impact on HLA-DM catalytic activity.
The structure of the HLA-DM-HLA-DR complex shows major rearrangements of the HLA-DR peptide-binding groove.
DMA*01:01 (69.35%) and DMB*01:01 (52.5%) alleles were more frequent in Chinese Hans
Multiple mechanisms, operating along the biosynthetic pathway of class II molecules, contribute to DM-mediated increases in the abundance of low-CLIP-affinity alleles.
HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians.
The results suggest that HLA-DMA*0104 may represent a novel allele of susceptibility to systemic lupus erythematosus.
HLA-DMA may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism.
The absence of HLA-DR/DM interactions at the limiting membrane prevents local loading of MHC class II molecules in phagosomes
glycosylation promotes, but is not essential for, DMalphabeta ER exit; single DMalpha chains cannot fully oxidize without DMbeta, while DMbeta forms disulfide-linked homodimers without DMalpha
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
RT1 class II, DM alpha
, MHC class II-like alpha chain
, major histocompatibility complex, class II, DM alpha
, H2-M alpha
, class II histocompatibility antigen, M alpha chain
, histocompatibility 2, class II, locus Ma
, HLA class II histocompatibility antigen, DM alpha chain
, MHC class II antigen DMA
, really interesting new gene 6 protein