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The results suggest that the GCKR and G6PC2 genes may contribute to the risk of type 2 diabetes independently and/or in an interactive manner in the Han Chinese population.
Results show that GCKR was associated with hypertriglyceridemia in Mexican Mestizos but not in Mexican Amerindians.
The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (show MLXIPL Proteins) (rs3812316) with dyslipidemia in an Iranian population.
genome-wide association study in US: Data suggest, among white subjects, an SNP in RCN3 (rs34459162) and a missense mutation in GCKR (rs1260236) are associated with serum levels of glycated albumin; among black subjects, an intergenic SNP in PRKCA (rs2438321) is associated with fructosamine levels and an intronic variant in PRKCA (rs59443763) is associated with glycated albumin levels. (RCN3 = reticulocalbin-3)
Interaction of any alcohol exposure with GCKR (rs780094) and A1CF (show A1CF Proteins) (rs10821905) influenced the risk of gout in Europeans
GCKR rs780094-C is associated with increased risk of gestational diabetes mellitus.[meta-analysis]
Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc.
Three loci showed robust, replicating association with circulating FXI (show F11 Proteins) levels: KNG1 (show KNG1 Proteins) (rs710446, P-value = 2.07 x 10-302), F11 (show F11 Proteins) (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI (show F11 Proteins) regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin (show F3 Proteins) time
GCKR association with adiposity and the risk of the nonalcoholic fatty liver disease
The existence of a liver-specific FOXA2 (show FOXA2 Proteins)-regulated transcriptional enhancer at an intronic T2D locus represented by rs780094, rs780095, and rs780096 SNPs that increases GCKR expression is demonstrated.
This study showed that Sirt2 (show SIRT2 Proteins)-dependent GKRP deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.
Given that acetylated GKRP may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP acetylation in the liver could reveal novel targets within the GK-GKRP pathway, for treating T2DM and other metabolic pathologies.
Glucokinase regulatory protein binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
glucokinase regulatory protein
, glucokinase regulator
, LOW QUALITY PROTEIN: glucokinase regulatory protein
, glucokinase (hexokinase 4) regulator