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CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites.
characterization the trafficking and surface expression of KA2
GRIK 5 gene (show GPD1 Proteins) is linked to rapid-onset dystonia-parkinsonism.
Functional dysregulation of glutamate (show GRIN1 Proteins) uptake was associated with early increases in mRNA and protein expression of the glial glutamate transporter EAAT (show SLC1A3 Proteins)-2 (show SLC1A2 Proteins) followed by a sustained decrease in mRNA expression in astrocytes infected with both HHV-6A & HHV-6B.
This study demonistrated that Grik5 gene expression in mouse dorsal raphe nucleus
Postsynaptic and presynaptic mossy-fiber kainate receptor function is altered in neurons from KA2-/- mice; presynaptic facilitatory autoreceptor had a reduced affinity for exogenous agonists and synaptic glutamate (show GRIN1 Proteins)
Association between COPI proteins and KA2 subunits was significantly reduced upon alanine substitution of this signal in the cytoplasmic tail of KA2.
Trafficking motifs in both intracellular loop and C terminus regulate KA2 surface expression; however, in neurons, GluR6 (show GRIK2 Proteins) oligomerization is required for egress of KA2 from endoplasmic reticulum and transport to cell surface.
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.
glutamate receptor ionotropic kainate 5
, glutamate receptor, ionotropic kainate 5
, ionotropic glutamate receptor subunit KA2
, glutamate receptor, ionotropic, kainate 5
, kainate type glutamate receptor 6
, glutamate receptor, ionotropic, kainate 2
, excitatory amino acid receptor 2
, glutamate receptor KA-2
, glutamate receptor KA2
, glutamate receptor ionotropic, kainate 5
, gluR gamma-2
, glutamate receptor gamma-2