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Human LIM Domain Kinase 1 Primary Antibody for IHC - ABIN966484
Ohashi, Nagata, Maekawa, Ishizaki, Narumiya, Mizuno: Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. in The Journal of biological chemistry 2000
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Human Polyclonal LIM Domain Kinase 1 Primary Antibody for IHC - ABIN966485
Soosairajah, Maiti, Wiggan, Sarmiere, Moussi, Sarcevic, Sampath, Bamburg, Bernard: Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. in The EMBO journal 2005
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Human Polyclonal LIM Domain Kinase 1 Primary Antibody for ICC, IF - ABIN4330979
Park, Agnihotri, Golbourn, Bertrand, Luck, Sabha, Smith, Byron, Zadeh, Croul, Berens, Rutka: Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway. in Oncotarget 2014
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Human Polyclonal LIM Domain Kinase 1 Primary Antibody for IF, IHC - ABIN362108
Edwards, Sanders, Bokoch, Gill: Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. in Nature cell biology 1999
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Human Polyclonal LIM Domain Kinase 1 Primary Antibody for ICC, IF - ABIN4330977
Gupta, Yadav, Pavuluri, Morley, Stairs, Dravid: Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity. in Neuropharmacology 2015
The present study demonstrates that miR (show MLXIP Antibodies)-145 plays an important role in inhibiting cell migration by directly targeting PAK4 (show PAK4 Antibodies), and identifies miR (show MLXIP Antibodies)-145-PAK4 (show PAK4 Antibodies)-LIMK1-cofilin (show CFL1 Antibodies) as a novel regulatory pathway that contributed to colorectal cancer metastasis.
In turn, LIMK1 and LIMK2 (show LIMK2 Antibodies) are required for MT1-MMP (show MMP14 Antibodies)-dependent matrix degradation and cell invasion in a three-dimensional type I collagen environment.
increased BMPR2 (show BMPR2 Antibodies) signal transduction is linked to fragile X (show FMR1 Antibodies) syndrome (FXS) and that the BMPR2 (show BMPR2 Antibodies)-LIMK1 pathway is a putative therapeutic target in patients with FXS and possibly other forms of autism
Report structural basis for noncanonical substrate recognition of cofilin-1/LIMK1 to regulation actin cytoskeleton dynamics.
LIMK1 expression is negatively regulated in granular layers-negative psoriatic epidermis or IL-22 (show IL22 Antibodies)/IL-24 (show IL24 Antibodies)-treated hyperproliferative reconstituted epidermis. These findings suggest a novel regulatory mechanism and a potent role of LIMK1 in psoriatic epidermis.
Therefore, miR (show MLXIP Antibodies)-138/LIMK1/cofilin (show CFL1 Antibodies) may be considered a potential therapeutic target for the treatment of non-small cell lung cancer
This study showed that LIMK1 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples.
Gene knockdown/rescue experiments reveal that LIMK1 palmitoylation is essential for normal spine actin polymerization, for spine-specific structural plasticity and for long-term spine stability.
LIMK1 is overexpressed in endometrial stromal cells.
Data show that the downregulation of miR (show MLXIP Antibodies)-138 induced the upregulation of Limk1 in ovarian cancer (OC) cells suggesting that these 2 genes may play a key role in the migration and invasion of OC cells.
bone morphogenetic protein receptor II (BMPRII (show BMPR2 Antibodies)) is a major regulator of LIMK1 in extending RGC axons, as expression of a BMPRII (show BMPR2 Antibodies) lacking the LIMK1 binding region caused a dramatic shortening of the axons
The spontaneous autosomal recessive mouse 'peroneal muscular atrophy' mutant (PMA) is a faithful morphological model of human clubfoot. The pma mutation was mapped and a candidate gene encoding LIM-domain kinase 1 (Limk1) identified, which is upregulated in mutant lateral motor neurons.
High LIMK1 expression is associated with aberrant synaptic development in mouse and Drosophila models of Fragile X (show FMR1 Antibodies) syndrome.
we define how ROCK/LIMK pathway regulates mast cell development and functions
LIMK1 negatively regulated neuronal migration by affecting the neuronal cytoskeleton and that its effects were partly mediated by cofilin (show CFL1 Antibodies) phosphorylation
Social isolation resulted in up-regulation of Limk-1 mRNA expression in the cerebral cortex.
The data emphasize the importance of the PLCeta2 EF-hand domain and articulation of PLCeta2 with LIMK-1 in regulating neuritogenesis.
Our study indicates that there is a connection between LIMK1 and AD in the mouse model of AD.
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.
LIMK1 and Cofilin (show CFL1 Antibodies) phosphorylation depends on PKA and is essential for mouse sperm acrosomal exocytosis
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
LIM domain kinase 1
, LIM motif-containing protein kinase
, LIM motif-containing protein kinase 1
, LIM-domain containing protein kinase 1
, LIM-domain containing, protein kinase 1