Browse our anti-Gap Junction Protein, beta 1, 32kDa (GJB1) Antibodies

Full name:: anti-Gap Junction Protein, beta 1, 32kDa Antibodies (GJB1)

On www.antibodies-online.com are 227 Gap Junction Protein, beta 1, 32kDa (GJB1) Antibodies from 22 different suppliers available. Additionally we are shipping Gap Junction Protein, beta 1, 32kDa Kits (31) and Gap Junction Protein, beta 1, 32kDa Proteins (5) and many more products for this protein. A total of 269 Gap Junction Protein, beta 1, 32kDa products are currently listed.

Synonyms:: AI118175, CMTX, CMTX1, Cnx32, connexin-30, connexin32, cx30, Cx32, gja1, Gjb-1, GJB1, gjb1-a, GJIC

list all antibodies	Gene Name	GeneID	UniProt
	GJB1	14618	P28230
	GJB1	29584	P08033
	GJB1	2705	P08034
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Most Popular Reactivities for anti-Gap Junction Protein, beta 1, 32kDa (GJB1) Antibodies

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Top referenced anti-Gap Junction Protein, beta 1, 32kDa Antibodies

Human Polyclonal GJB1 Primary Antibody for IHC (p), WB - ABIN965915 : Corcos, Lafrenière, Begy, Loch-Caruso, Willard, Glover: Refined localization of human connexin32 gene locus, GJB1, to Xq13.1. in Genomics 1992 (PubMed)
Show all 2 Pubmed References
Cow (Bovine) Polyclonal GJB1 Primary Antibody for IHC, WB - ABIN2774855 : Dagli, Yamasaki, Krutovskikh, Omori: Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver. in Carcinogenesis 2004 (PubMed)
Show all 2 Pubmed References
Rat (Rattus) Monoclonal GJB1 Primary Antibody for FACS, IF - ABIN5578830 : Goodenough, Paul, Jesaitis: Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions. in The Journal of cell biology 1988 (PubMed)

More Antibodies against Gap Junction Protein, beta 1, 32kDa Interaction Partners

Mouse (Murine) Gap Junction Protein, beta 1, 32kDa (GJB1) interaction partners

Blocking of connexin32 or connexin43 (show GJA1 Antibodies) hemichannels decreased serum levels of pro-inflammatory cytokines, and reduced acetaminophen-induced liver injury.
The results of this study indicated that the Leu89Pro substitution in the second transmembrane domain of CX32 disrupts the trafficking of the protein, inhibiting the assembly of CX32 gap junctions, which in turn may result in peripheral neuropathy.
We show that the cell-surface and secreted isoforms of CSF-1 (show CSF1 Antibodies) have opposing effects on macrophage activation and disease progression in a mouse model of connexin32-deficientconnexin32-deficient mice
Results identify CSF-1 (show CSF1 Antibodies)-activated macrophages as crucial mediators of detrimental Schwann cell dedifferentiation in Cx32-deficient mice
Blockade of endothelial Cx32 increased tissue factor (show F3 Antibodies) expression induced by TNF-alpha (show TNF Antibodies) stimulation and cell-cell interaction via ICAM1 (show ICAM1 Antibodies). Direct Cx32-mediated interaction modulates TF expression in ECs during vascular inflammation.
These findings support a role for Cx32 in non-myelinating and regenerating populations of Schwann cells in normal axonal maintenance in re-myelination, and regeneration of peripheral nerve following injury
Connexin32 interacts with connexin26 (show GJB2 Antibodies) and the mitochondrial protein (show COX6B2 Antibodies), sideroflexin-1 (show SFXN1 Antibodies), at the plasma membrane forming a novel signaling nexus.
These results demonstrate that the incidence of hepatocellular carcinoma increases only in male Cx32KO mice, presumably due to enhanced tumor promotion and progression signals associated with Cx32 deficiency.
Cx32 is differentially phosphorylated and exists in a complex with SAP97 and CaM.
Cx32 therapy improves gap junctional conductance results in larger infarct size, and no antiarrhythmic efficacy.

Human Gap Junction Protein, beta 1, 32kDa (GJB1) interaction partners

These "periferal nervous system-only" mutations form gap junction plaques and produce levels of junctional coupling similar to those for wild-type Cx32. In contrast, mutants with central nervous system manifestations either form no morphological gap junction plaques or, if they do, produce little or no detectable junctional coupling.
Results show that the GJB1 (connexin 32; Cx32) mutants R75P, R75Q and R75W display variable structural conformation and dynamic behavior compared to the native protein.
Point mutation of GJB1 gene, encoding connexin 32, is associated with X-linked Charcot-Marie-Tooth disease.
Cx32 regulates the sensitivity of hepatocellular carcinoma cells to doxorubicin via the Src (show SRC Antibodies)/FAK (show PTK2 Antibodies) signaling pathway
Study verifies that Cx32 exerts an inhibitory effect on extrinsic apoptosis in cervical cancer (CaCx) cells, and suggests that Cx32 may regulate the progression and micro-environment of CaCx cells.
Cx32 is essential for cell-cell interactions that facilitate driving hESCs through hepatic-lineage maturation.
Study provides a novel mechanism for Cx32's anti-apoptotic effect and provides a reasonable explanation for the pro-tumor effect of Cx32 in human cervical cancer cells.
Genetic analysis revealed a total of 43 mutations including 6 novel mutations. Ten mutations were found from two or more unrelated families. p.V95M was most frequently observed. The frequency of CMTX1 was 9.6% of total Korean CMT family and was 14.8% when calculated within genetically identified cases
PBX1 (show PBX1 Antibodies) is one of the determinants in the Cx32 promoter targeting site, preventing further damage of gap junction protein in H. pylori-associated gastric carcinogenesis.
Study describes a novel mutation deleting entire P2 promoter of GJB1 gene in a single large family with X-linked Charcot-Marie-Tooth disease. Inheritance and phenotype of affected individuals had classical features of X linked peripheral neuropathy. This study affirms the role of P2 promoter being vital for Schwann cell function.

Cow (Bovine) Gap Junction Protein, beta 1, 32kDa (GJB1) interaction partners

intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (show GJB2 Antibodies), Cx32, and Cx43 (show GJA1 Antibodies)

Gap Junction Protein, beta 1, 32kDa (GJB1) Antigen Profile

Antigen Summary

This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Gap Junction Protein, beta 1, 32kDa (GJB1)

gap junction protein beta 1 (gjb1) antibody
connexin 32 (CX32) antibody
probable serine/threonine-protein kinase CST (LOC9303136) antibody
gap junction protein beta 1 (GJB1) antibody
gap junction protein, beta 1 (Gjb1) antibody
gap junction protein beta 1 (Gjb1) antibody
gap junction protein beta 1 L homeolog (gjb1.L) antibody

AI118175 antibody
CMTX antibody
CMTX1 antibody
Cnx32 antibody
connexin-30 antibody
connexin32 antibody
cx30 antibody
Cx32 antibody
gja1 antibody
Gjb-1 antibody
GJB1 antibody
gjb1-a antibody
GJIC antibody

Protein level used designations for GJB1

connexin 30 , connexin 32 , gap junction protein, beta 1, 32kDa , connexin-32 , connexin-43 , gap junction beta-1 protein , gap junction membrane channel protein beta 1 , GAP junction 28 kDa liver protein , connexin32 , cx32 , gap junction protein, beta 1, 32 kD , gap junction protein beta 1 , connexin-30 , cx30

GENE ID	SPECIES
407921	Xenopus (Silurana) tropicalis
443234	Ovis aries
9303136	Arabidopsis lyrata subsp. lyrata
465696	Pan troglodytes
706327	Macaca mulatta
14618	Mus musculus
29584	Rattus norvegicus
100379282	Cavia porcellus
2705	Homo sapiens
378797	Gallus gallus
480953	Canis lupus familiaris
281194	Bos taurus
100008934	Oryctolagus cuniculus
100034021	Equus caballus
394373	Xenopus laevis

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