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anti-Human GJC1 Antibodies:
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Human Polyclonal GJC1 Primary Antibody for IHC (p), ELISA - ABIN544551
Kanter, Saffitz, Beyer: Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45. in Journal of molecular and cellular cardiology 1994
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Human Polyclonal GJC1 Primary Antibody for IHC (p), WB - ABIN388379
Li, Sekhon, Barr, Márquez-Rosado, Lampe, Kidder: Connexins and steroidogenesis in mouse Leydig cells. in Canadian journal of physiology and pharmacology 2013
Horse (Equine) Polyclonal GJC1 Primary Antibody for WB - ABIN2774871
Terrier-Lacombe, Guillou, Maire, Terrier, Vince, de Saint Aubain Somerhausen, Collin, Pedeutour, Coindre: Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group. in The American journal of surgical pathology 2002
Show all 2 Pubmed References
Human Polyclonal GJC1 Primary Antibody for WB - ABIN3042424
Zeng, Li, Li, Li, Xiao, Chu, Yang: Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats. in Bioengineered 2017
Human Polyclonal GJC1 Primary Antibody for ELISA, ICC - ABIN6260966
Zhao, Wu, Chen, Ji, Zheng: TGF-β1 and connexin-43 expression in neurogenic bladder from rats with sacral spinal cord injury. in Neurourology and urodynamics 2018
our data highlighted the critical role of CX45 in reprogramming and may increase the cell division rate and result in an accelerated kinetics of iPSCs production.
human Cx40/Cx45 and Cx43/Cx45 heterotypic gap junctions were investigated by recombinant expression in GJ deficient cells.
Observations involving both N- and C-domains of CaM to interact with the Cx45 peptide differ from the embraced interaction with Cx50 from another connexin family
Human deltoid muscle biopsies of 5 Chilean dysferlinopathy patients exhibited the presence of muscular connexins (Cx40.1, Cx43 and Cx45).
Connexin45 has much more rapid gating kinetics than connexin43
Results found that the expression of Cx26 and Cx45 had no prognostic value but Cx43 was upregulated in tumour epithelia and membrane Cx43 expression was associated with short overall survival time.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45.
Our data suggest that GJA7 alterations have no or low genetic relevance in nonsyndromic hearing loss in populatins from Turkey, South Africa, United Kingdom, United States, and China.
DNA hypermethylation of the promoter region of GJC1, encoding connexin45, is an important mechanism in silencing gene expression in colorectal cancer.
Study shows that fusion of a V5/6-His tag (hexa moiety M r = 0.93 kDa) to the CT segment of Cx40, Cx43 and Cx45 does not prevent the cells from forming channels.
connexin genes Gjd2 coding for mCx36, Gjc1 coding for mCx45 and Gja10 coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59) and GJA10 (Cx62), could be detected at least as transcript isoforms in the human retina.
Results show that Cx40, Cx37, Cx43 and Cx45 were expressed within the glomeruli.
Studies indicate that 21 different Cxs have been detected and they are generally named according to their approximate molecular mass in Kda, e.g. Cx32, Cx43 and Cx45.
Data suggest that the dynamic changes of connexins 43, 40 and 45 during mouse cardiac development appear to be mirrored in the human.
abnormal expression of connexin43 and connexin45 in nasopharynx tissues may be associated with cancerization and squamatization of human nasopharynx tissue
mRNA levels of connexins in different sizes of luteinized normal and hyperstimulated follicles.
The staining patterns for Cx45 rather were typified by granular cytoplasmic staining.
Cx45 has a complex binding interaction with zonula occludens-1 (ZO-1) that involves either an extended carboxyl terminal domain or two distinct binding sites.
Cx40/Cx45 junctions demonstrate electrical signal transfer asymmetry that can be modulated between unidirectional and bidirectional by small changes in the difference between holding potentials of the coupled cells.
a cross-talk between CFTR and a variety of gap junction channels. Cytoskeletal scaffolding proteins and/or other intermediate cytoplasmic proteins are likely to play a role in CFTR-connexins interaction.
the levels of mRNAs encoding Connexin43 or Connexin45 were not or were only marginally affected, respectively, by Clmp deficiency, the absence of CLMP caused a severe reduction of both proteins in smooth muscle cells of the intestine and of Connexin43 in the ureter.
Punctate labelling of Cx45 was faint in the cerebellar cortex molecular layer of wild-type mice and was increased in intensity in mice with Cx36 gene ablation. The vast majority of Cx36-puncta co-localized with Cx45-puncta, which in turn was associated with the scaffolding protein zonula occludens-1.
Results indicate that pre- and peri-implantation development does not require connexin43 (Cx43) and connexin45 (Cx45).
These data indicate a fine regulation of the gap junction channel make-up in function of the type and the ratio of co-expressed connexins that specifically regulates chemical and electrical coupling.
connexin45 carboxyl-terminal domain structure and interactions with molecular partners
The ablation of Cx45 reduced neuronal loss by approximately 50% under ischemic insult.
This study demonstrated using Cx45-eGFP transgenic mice that Cx45-eGFP cells are distributed along the rostrocaudal extent of the spinal cord with expression mainly restricted to the grey matter of dorsal laminae I-III
Connexins 36 and 45 could be involved in supporting Leydig cell steroidogenesis.
Prostaglandin E stimulates Connexin isoforms via GSK-3beta/beta-catenin via EP2-receptor-dependent cAMP/PKA and PI3K/Akt in mouse embryonic stem cells.
Suggest critical role for Cx45 in the regulation of endothelial-induced mesenchymal cell differentiation towards a mural cell phenotype.
Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone.
Cx45 is required for optimal impulse propagation in the atrioventricular node; cardiomyocyte-directed deficiencies of Cx45 in mice lead to embryonic lethality attributable to morphological and functional cardiovascular defects.
Cx45 is physiologically expressed in vascular smooth muscle
Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium.
The cx45 strongly modulate the firing pattern of individual RGCs, ensuring strongly correlated firing between nearby RGCs and normal patterning of retinogeniculate projections.
Data suggest that Cx45 is expressed on OFF bipolar cell dendrites, presumably forming gap junctions with cells of the same type, and on OFF bipolar cell axon terminals, presumably forming heterologous gap junctions with other retinal neurons.
Data suggest that Cx45 and Cx36 have similar functions in the retina, whereas Cx45 fulfills special functions in the developing heart that cannot be compensated by Cx36.
The neuron-directed deletion of Cx45 impaired one-trial novel object recognition and altered kainate-induced gamma-oscillations possibly via the disruption of inter-neuronal gap junctional communication in the hippocampus or perirhinal cortex.
data suggests that connexin 45 and ZO-1 directly interact in osteoblastic cells (ROS/Cx45)
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.
, gap junction alpha-7 protein
, gap junction gamma-1 protein
, gap junction protein, gamma 1, 45kDa
, gap junction protein, alpha 7, 45kDa (connexin 45)
, gap junction protein, delta 3, 31.9kDa
, gap junction protein, alpha 7, 45kDa
, gap junction membrane channel protein alpha 7
, gap junction gamma-1 protein-like
, gap junction channel protein connexin 45
, Gap junction alpha-7 protein