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anti-Mouse (Murine) LIM2 Antibodies:
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Human Polyclonal LIM2 Primary Antibody for WB - ABIN2783982
Wistow, Bernstein, Wyatt, Behal, Touchman, Bouffard, Smith, Peterson: Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. in Molecular vision 2002
Show all 2 Pubmed References
A novel missense mutation in the Lim2 (show LHX2 Antibodies) gene affects lens development in a semidominant manner. Since homozygous mutants develop congenital lens opacities, this mouse line can be used as a model for inherited cataract formation in humans.
Data show that the calcium- and integrin-binding protein CIB (show CIB1 Antibodies) as an LMO3 (show LMO3 Antibodies)-binding protein, which binds via the second LIM (show PDLIM5 Antibodies) domain (LIM2 (show LHX2 Antibodies)) of LMO3 (show LMO3 Antibodies).
A novel missense mutation in LIM2 is responsible for autosomal recessive congenital cataracts.
The genetic mutation in GJA3 (show GJA3 Antibodies), GJA8 (show GJA8 Antibodies), and LIM2 may slightly contribute to the development of age-related cataracts.
Since the LIM2 gene promoter does not contain a classic TATA box, the Hsu element may serve as the site for binding the RNA polymerase complex.
A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family
This study shows the involvement of LIM2 in human congenital cataract.
This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, lens fiber membrane intrinsic protein
, total opacity 3
, lens intrinsic membrane protein 2, 19kDa
, intrinsic membrane protein 2