Browse our anti-Neurofibromin 2 (NF2) Antibodies

Human Neurofibromin 2 (NF2) interaction partners

1. Study identified missense NF2 mutations in 1.9% hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and 5.3% intrahepatic cholangiocarcinoma (ICC). Allele frequency of NF2 IVS4-39 A/A was significantly higher in HCCs (show HCCS Antibodies). Also, NF2/Merlin showed a dual role as a tumorigenic gene and tumor-suppressor gene; Merlin was expressed at higher levels in HCC (show FAM126A Antibodies) tumors ; while the rate of Merlin upregulation was lower in poorly differentiated ICCs.

2. This study demonstrates that simultaneous inhibition of c-Met and Src (show SRC Antibodies) signaling in MD-MSCs triggers apoptosis and reveals vulnerable pathways that could be exploited to develop NF2 therapies.

3. These results indicate that Merlin/YAP (show YAP1 Antibodies)/cMyc (show MYC Antibodies)/mTOR (show FRAP1 Antibodies) signaling axis promotes human cholangiocarcinoma (CCA (show FBN2 Antibodies)) cell proliferation by overriding contact inhibition. We propose that overriding cMycmediated contact inhibition is implicated in the development of CCA (show FBN2 Antibodies).

4. The genetic alterations observed in the NF2 gene indicated that spinal schwannomas are associated with genetic alterations also found in other schwannomas and type 2 Neurofibromatosis, which reinforces the etiological role of this gene.

5. Methylation of NF2 and DNMT1 (show DNMT1 Antibodies) was markedly increased, and miR (show MLXIP Antibodies)-152-3p was downregulated in GBM tissues and glioma cells. Both knockdown of DNMT1 (show DNMT1 Antibodies) and overexpression miR (show MLXIP Antibodies)-152-3p showed that demethylation activated the expression of NF2.

6. The acquired sensitivity to erlotinib supports the known crosstalk between MET and the HER family of receptors. For the first time, we show inactivation of NF2 during acquisition of resistance to MET-TKI that may explain the refractoriness to erlotinib in these cells.

7. Genetic data coupled with transcriptomic data allowed the identification of a new malignant pleural mesothelioma (MPM)molecular subgroup, C2(LN), characterized by a co-occurring mutation in the LATS2 and NF2 genes in the same MPM. MPM patients of this subgroup presented a poor prognosis. Coinactivation of LATS2 and NF2 leads to loss of cell contact inhibition between MPM cells

8. The occurrance and evolvement of sporadic intraspinal Schwannomas have a close relationship with mutations of the NF2 gene.

9. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.

10. An independent set of Sarcomatoid Renal Cell Carcinoma (show MOK Antibodies) demonstrated mutations in NF2. NF2 mutations were mutually exclusive with TP53 (show TP53 Antibodies) but not with VHL (show VHL Antibodies) mutations.

Mouse (Murine) Neurofibromin 2 (NF2) interaction partners

1. Loss of Nf2 causes hyperplasia and ocular abnormalities.

2. studies suggest that NF2 normally limits biliary morphogenesis by coordinating lumen expansion and cell architecture. This work provides fundamental insight into how biliary fate and tubulogenesis are coordinated during development and will guide analyses of disease-associated and experimentally induced biliary pathologies.

3. Data show that early Smarcb1 (show SMARCB1 Antibodies) loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.

4. Rho attenuates the interaction between Amot (show AMOT Antibodies) and Nf2 by binding to the coiled-coil domain of Amot (show AMOT Antibodies).

5. co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by Nf2 loss, which can be suppressed either by treatment with pro-oxidants or by co-deletion of Yap (show YAP1 Antibodies).

6. Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP (show YAP1 Antibodies) signaling activity.

7. NF2 is activated by oxidative stress in cardiomyocytes and myocardium and facilitates apoptosis.

8. loss of axonal contact following nerve injury results in merlin phosphorylation leading to increased p75(NTR (show NGFR Antibodies)) expression.

9. Loss of Nf2 and Cdkn2a/b have synergistic effects with PDGF-B (show PDGFB Antibodies) overexpression promoting meningioma malignant transformation.

10. Merlin 1 and 2 act as tumor suppressors and are required for optimal sperm maturation

Zebrafish Neurofibromin 2 (NF2) interaction partners

1. Mutation of nf2 gene develops extrahepatic choledochal cysts in the common bile duct

Xenopus laevis Neurofibromin 2 (NF2) interaction partners

1. NF2/Merlin negatively regulates the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling activity during the pattern formation in early embryos.