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anti-Human Plakophilin 4 Antibodies:
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Human Polyclonal Plakophilin 4 Primary Antibody for WB - ABIN1881657
Hatzfeld, Nachtsheim: Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. in Journal of cell science 1997
Show all 5 Pubmed References
Human Monoclonal Plakophilin 4 Primary Antibody for ELISA, WB - ABIN521945
Teh, Parkinson, Thurlow, Liu, Fortune, Wan: A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma. in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2011
Data show that patients with both abnormal expression of p0071 and E-cadherin (show CDH1 Antibodies) had a statistically significant shorter survival than the patients without both abnormal expression.
p0071 has a key role in regulating recycling through the Rab11a (show RAB11A Antibodies)-dependent perinuclear recycling compartment.
This review article focuses on the functions of the p0071 protein and its closest relatives in regulating cell adhesion and cytoskeletal organization, which are critically involved in the control of cell polarity. [review]
Findings suggest that aspects of folliculin (show FLCN Antibodies) tumour suppressor function are linked to interaction with p0071 and the regulation of RhoA (show RHOA Antibodies) signalling.
These data support a model in which dysregulation of the FLCN (show FLCN Antibodies)-p0071 interaction leads to alterations in cell adhesion, cell polarity, and RhoA (show RHOA Antibodies) signaling.
The structural and functional roles of p0071 are suggested by its preferential occurrence in distinct tubule segments, and its potential use as a cytodiagnostic cell type marker in renal pathology is discussed.
ERBIN (show ERBB2IP Antibodies) interacts in vivo with p0071 and that it may be involved in the organization of adherens junctions and the desmosomes of epithelia
In addition to plakoglobin (show JUP Antibodies), p0071 is the second armadillo (show PKP1 Antibodies) protein present in both types of adhesive junctions and may play a role in regulating crosstalk between adherens junctions and desmosomes.
p0071 bound to the first 160 amino-terminal residues of desmoplakin (show DSP Antibodies) and also interacted directly with plakoglobin (show JUP Antibodies), suggesting that p0071 may regulate desmosome assembly by controlling plakoglobin (show JUP Antibodies) availability
These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis.
results identify p0071 as an important and novel FMRP (show FMR1 Antibodies) target and strongly suggest that impaired actin cytoskeletal functions mediated by an excess of p0071 are key aspects underlying the fragile X (show FMR1 Antibodies) syndrome
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms.
, armadillo-related protein
, plakophilin 4