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anti-Human SORBS1 Antibodies:
anti-Mouse (Murine) SORBS1 Antibodies:
anti-Rat (Rattus) SORBS1 Antibodies:
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Human Polyclonal SORBS1 Primary Antibody for ELISA - ABIN547642
Matson, Pare, Kapiloff: A novel isoform of Cbl-associated protein that binds protein kinase A. in Biochimica et biophysica acta 2005
Human Polyclonal SORBS1 Primary Antibody for ELISA - ABIN547874
Baumann, Ribon, Kanzaki, Thurmond, Mora, Shigematsu, Bickel, Pessin, Saltiel: CAP defines a second signalling pathway required for insulin-stimulated glucose transport. in Nature 2000
Human Polyclonal SORBS1 Primary Antibody for IHC (p), IHC - ABIN249546
Ribon, Printen, Hoffman, Kay, Saltiel: A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. in Molecular and cellular biology 1998
Human Polyclonal SORBS1 Primary Antibody for ICC, IF - ABIN4355166
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
SORBS1 suppresses tumor metastasis and improves the sensitivity of breast cancer cells to antineoplastic agents.
association between common SORBS1 genetic variations and blood pressure, presence of hypertension, and age at onset of hypertension
data suggest that SORBS1 might be a gene involved in diabetic nephropathy.
Our NMR and ITC data indicate that the SH3a and SH3b domains of CAP simultaneously bind to a long proline-rich region of vinculin (show VCL Antibodies) with different binding specificities
Sequestration of the ponsin splice variant R85FL by the polyglutamine-expanded Atx7 in cell is mediated by the specific SH3C-PRR interaction, which is implicated in the pathogenesis of spinocerebellar ataxia 7.
a novel signaling network containing FRS2 (show FRS2 Antibodies), CAP and flotillin-1 (show FLOT1 Antibodies)
The novel ponsin isoform and its interaction with Nck1 (show NCK1 Antibodies)/2 provide exciting insight into the convergence of signalling pathways at the costameres, and its crucial role for skeletal muscle differentiation and re-generation.
preliminary results indicate the depot-specific differential expression of sorbin and SH3 domain-containing-1(SORBS1) in relation to body mass index
SORBS1 polymorphism does not play a major role in premature pubarche, hyperandrogenism, and/or polycystic ovary syndrome in children and adolescent girls.
Soluble intracellular domain of teneurin-1 (show ODZ1 Antibodies) binds to the cell membrane enriched in CAP/ponsin
The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 (show SKOR2 Antibodies) . The second SNP rs30415957 resides in the intron of Plce1 (show PLCE1 Antibodies).The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2
The study screened CrkL (show CRKL Antibodies) binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 (show Sorbs2 Antibodies) as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.
Suggest a novel modulatory role for CAP in the heart as a key protein stabilizing antiviral type I interferon (show IFNA Antibodies) production, while protecting from excessive cytotoxic responses in CVB3 mediated endocarditis.
Low- and high-dose ursolic acid can improve the glycometabolism and differentiation of 3T3-L1 adipocytes with insulin (show INS Antibodies) resistance by up-regulating the expression of CAP.
CAP, Cbl (show CBL Antibodies) iso-forms, and CrkII (show CRK Antibodies) are not required components of insulin (show INS Antibodies) signaling to GLUT4 (show SLC2A4 Antibodies) transporters
Bone marrow-specific Sorbs1 (Cap) gene deletion protects against high-fat diet-induced insulin (show INS Antibodies) resistance.
These data provide a mechanism for the lipid raft localization of TrkA (show NTRK1 Antibodies) and establish the importance of the CAP adaptor protein for nerve growth factor activation of the extracellular signal-regulated kinase and neuronal differentiation.
Polymorphisms in promoter regions of PDHB (show PDHB Antibodies), SORBS1, and EDG1 (show S1PR1 Antibodies) genes showing marbling-associated expression changes.
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Fas-ligand associated factor 2
, SH3 domain protein 5
, SH3-domain protein 5 (ponsin)
, c-Cbl associated protein
, c-Cbl-associated protein
, sorbin and SH3 domain-containing protein 1