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The central role of talin and vinculin (show VCL Proteins) in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM (show MMRN1 Proteins) interactions and remodeling of the tissue.
data suggest a potential molecular link between TLN2 and camptodactyly pathogenesis.
Both TLN-1 (show TLN1 Proteins) and TLN-2 levels correlate with tumorigenicity in human HCC (show FAM126A Proteins), indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma .
Data indicate the role of vinculin (show VCL Proteins) in inducing the talin mediated integrin activation.
Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.
Data show that SCGB3A1 (show SCGB3A1 Proteins) was down-regulated in invasive compared with DCIS, whereas talin 2 (TLN2) and PTGS1 (show PTGS1 Proteins) were up-regulated in invasive compared with DCIS.
This review discusses the general function of talin 1 (show TLN1 Proteins) and talin 2, as well as vinculin (show VCL Proteins)/metavinulin, with emphasis on what is understood about their role in the cardiac myocyte and in whole heart.
the differential concentration of CSF (show CSF2 Proteins) and serum-talin 2 in the drug-refractory postencephalitic epilepsy group is an intractability-related phenomenon that might be involved in the development of RPEE
The F-actin binding capacity of Talin 2 is regulated by intrasteric occlusion of primary actin-binding determinants within the talin I/LWEQ module.
Talin2 may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated (show NSDHL Proteins) muscle.
Binding of vinculin (show VCL Proteins) to the R1-R3 region of the talin rod is important for focal adhesion stability.
Data indicate that talin mechanics are isoform specific so that expression of either talin-1 (show TLN1 Proteins) or talin-2 modulates extracellular rigidity sensing.
Tln2(cd/cd (show CTSD Proteins)) mice showed no major difference in body mass or the weight of the major organs compared to wild-type, although they displayed a mildly dystrophic phenotype.
Talin1 was concentrated in peripheral focal adhesions while talin2 was observed in both focal and fibrillar adhesions, and knock-down of talin2 compromised fibronectin (show FN1 Proteins) fibrillogenesis
Fxr1 knockout hearts exhibit an up-regulation of desmoplakin and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
Depletion of talin2 in talin1-null cells did not affect the initiation of matrix-activated spreading or Src (show SRC Proteins) family kinase activation, but abolished the extracellular matrix-integrin-cytoskeleton linkage, sustained cell spreading and adhesion.
demonstrate that testis and kidney express truncated talin 2 isoforms that lack the N-terminal half of the protein, and provide evidence for the developmentally regulated expression of the short testis-specific (show AIF1 Proteins) talin 2 isoform in elongating spermatids
Talin 1 (show TLN1 Proteins) and 2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of myotendinous (show TNC Proteins) junctions.
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.