Browse our anti-Vinculin (VCL) Antibodies

Full name:: anti-Vinculin Antibodies (VCL)

On www.antibodies-online.com are 198 Vinculin (VCL) Antibodies from 28 different suppliers available. Additionally we are shipping Vinculin Kits (41) and Vinculin Proteins (13) and many more products for this protein. A total of 267 Vinculin products are currently listed.

Synonyms:: 9430097D22, AA571387, AI462105, AW545629, CG3299, CMD1W, CMH15, CT11081, DDBDRAFT_0186762, DDBDRAFT_0232320, DDB_0186762, DDB_0232320, Dmel\\CG3299, Dmvincp, EG:103B4.1, hm:zehn2160, im:6902790, LOC100228062, MV, MVCL, VCL, vcl-A, Vin, Vin2EF, vinc

list all antibodies	Gene Name	GeneID	UniProt
	VCL	7414	P18206
	VCL	22330	Q64727
	VCL	305679	P85972
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Most Popular Reactivities for anti-Vinculin (VCL) Antibodies

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anti-Human Vinculin Antibodies:

anti-Mouse (Murine) Vinculin Antibodies:

anti-Rat (Rattus) Vinculin Antibodies:

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Relevant Pathways for anti-Vinculin Antibodies

Signaling Events mediated by VEGFR1 and VEGFR2

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Top referenced anti-Vinculin Antibodies

Human Polyclonal Vinculin Primary Antibody for IF (cc), IF (p) - ABIN719261 : Li, Sun, Yang, Hu, Jiang: Tanshinone II a protects against lipopolysaccharides-induced endothelial cell injury via Rho/Rho kinase pathway. in Chinese journal of integrative medicine 2014 (PubMed)
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Human Polyclonal Vinculin Primary Antibody for IHC (p), WB - ABIN3044168 : Lyu, Wang, Wang, Ding, Liu, Yuan, Shi, Wang, Wang, Chen: Maintaining the pluripotency of mouse embryonic stem cells on gold nanoparticle layers with nanoscale but not microscale surface roughness. in Nanoscale 2014 (PubMed)
Show all 3 Pubmed References
Chicken Monoclonal Vinculin Primary Antibody for IHC (fro), WB - ABIN3043674 : Lyu, Hu, Xu, Zhang: Dynamics of focal adhesions and reorganization of F-actin in VEGF-stimulated NSCs under varying differentiation states. in Journal of cellular biochemistry 2013 (PubMed)
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Amphibian Monoclonal Vinculin Primary Antibody for ICC, IHC (fro) - ABIN269480 : Chianale, Cutrupi, Rainero, Baldanzi, Porporato, Traini, Filigheddu, Gnocchi, Santoro, Parolini, van Blitterswijk, Sinigaglia, Graziani: Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling. in Molecular biology of the cell 2007 (PubMed)
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Bat Polyclonal Vinculin Primary Antibody for WB - ABIN611567 : Hou, Schindler, Henzel, Ho, Brasseur, McKnight: An interleukin-4-induced transcription factor: IL-4 Stat. in Science (New York, N.Y.) 1994 (PubMed)
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Human Monoclonal Vinculin Primary Antibody for IF, ELISA - ABIN563365 : Maghdessian, Côté, Rouleau, Ben Djoudi Ouadda, Levy, Lavoie: Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig. in The Journal of pharmacology and experimental therapeutics 2010 (PubMed)
Mouse (Murine) Monoclonal Vinculin Primary Antibody for IHC (fro), IHC (p) - ABIN289630 : Witt, Zieseniss, Fock, Jockusch, Illenberger: Comparative biochemical analysis suggests that vinculin and metavinculin cooperate in muscular adhesion sites. in The Journal of biological chemistry 2004 (PubMed)
Human Monoclonal Vinculin Primary Antibody for IP, IHC - ABIN284839 : Korte, Fröhlich, Kohn, Kaspers, Arnold, Härtle: 2-D DIGE analysis of the bursa of Fabricius reveals characteristic proteome profiles for different stages of chicken B-cell development. in Proteomics 2012 (PubMed)

More Antibodies against Vinculin Interaction Partners

Human Vinculin (VCL) interaction partners

Differential phosphatidylinositol 4,5-diphosphate binding of vinculin isoforms promotes quasi-equivalent dimerization.
Study used an all-heavy-atom structure-based model to study vinculin activation by talin in a high-tension context mechanically driven by F-actin, showed that vinculin activation may proceed from an intermediate state stabilized by partial talin-vinculin association. There is a low-force regime and a high-force regime where vinculin activation is dominated by two different pathways with distinct responses to force.
Vinculin head-tail interaction is required on soft substrates to destabilize vinculin and talin in FAs (show FAS Antibodies), and to allow hMSCs branching. Another module involves paxillin (show PXN Antibodies) and FAK (show PTK2 Antibodies), which soft substrates also destabilize, but independently of vinculin head-tail interaction. This multi-modularity may be key to allow a versatile response to complex biomechanical cues.
The central role of talin and vinculin in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM (show MMRN1 Antibodies) interactions and remodeling of the tissue.
East Asian common VCL variant p.Asp841His (D841H) was associated with sudden unexplained nocturnal death syndrome (SUNDS) in the Chinese Han population.
We identified mutations in VCL associated with Short segment Hirschsprung disease. Correction of this mutation in induced pluripotent stem cells using CRISPR/Cas9 editing, as well as the RET (show RET Antibodies) G731del mutation that causes Hirschsprung disease with total colonic aganglionosis, restored enteric neural crest cell function.
This review discusses the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. [review]
Study predicted the structure of the MAPK1 (show MAPK3 Antibodies)-vinculin binding interface using a combination of flexible docking and molecular dynamics simulations, and confirmed that the MAPK1 (show MAPK3 Antibodies)-vinculin interaction is mechanically regulated, and implicated a change in the vinculin D3-D4 cleft size upon vinculin activation as the basis for the conformational selectivity of MAPK1 (show MAPK3 Antibodies) binding toward open vinculin.
These results suggest that vinculin promotes the nuclear localization of transcription factor TAZ (show TAZ Antibodies) to inhibit the adipocyte differentiation on rigid extracellular matrix.
The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese

Zebrafish Vinculin (VCL) interaction partners

Study show that zebrafish contain two homologous vinculin isoforms, of which the sequence of key functional domains is conserved with several higher vertebrate. Loss of both zygotic vcla and maternal contribution of vcla did not result in notable defects, while the additional loss of zygotic vclb is lethal only after embryonic stages. These data indicate that embryonic development in zebrafish can occur without vinculin.

Pig (Porcine) Vinculin (VCL) interaction partners

Results suggest that myosin VI (show MYO6 Antibodies) and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.

Mouse (Murine) Vinculin (VCL) interaction partners

Lipid binding increases vinculin activation and turnover at focal adhesions.
results suggest that the vinculin-actin interaction participates in FA-mediated mechanotransduction
These results suggest that vinculin promotes the nuclear localization of transcription factor TAZ (show TAZ Antibodies) to inhibit the adipocyte differentiation on rigid extracellular matrix.
The results indicate that lipid rafts play an important role in extracellular matrix stiffness regulation of cell migration via expression vinculin and its interaction with vinexin alpha (show Sorbs3 Antibodies).
Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.
These data demonstrate that Src-mediated phosphorylation is necessary for vinculin activation, and that phosphorylation controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.
results suggest that vinculin promotes directionally persistent cell migration and tension-dependent ECM (show MMRN1 Antibodies) remodeling in complex 3D environments by increasing cell-ECM (show MMRN1 Antibodies) adhesion and traction force generation.
Force-dependent conformational switch of alpha-catenin (show CTNNA1 Antibodies) controls vinculin binding.
Mutant vinculin expressing cells are altered in cell migration, which is accompanied by changes in cell adhesion.
show that Src (show SRC Antibodies) phosphorylation of Y1065 within the C-terminal hairpin regulates Vt-mediated actin bundling and provide a detailed characterization of vinculin Y1065 mutations

Fruit Fly (Drosophila melanogaster) Vinculin (VCL) interaction partners

These findings demonstrate the crucial importance of the tight control of the activity of vinculin.

Vinculin (VCL) Antigen Profile

Antigen Summary

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Alternative names and synonyms associated with Vinculin (VCL)

vinculin (VCL) antibody
vinculin a (vcla) antibody
vinculin A (vinA) antibody
vinculin (Vcl) antibody
Vinculin (Vinc) antibody
vinculin (CpipJ_CPIJ013873) antibody
vinculin (Bm1_37935) antibody
vinculin (vcl) antibody
vinculin S homeolog (vcl.S) antibody
vinculin-like (LOC100356093) antibody

9430097D22 antibody
AA571387 antibody
AI462105 antibody
AW545629 antibody
CG3299 antibody
CMD1W antibody
CMH15 antibody
CT11081 antibody
DDBDRAFT_0186762 antibody
DDBDRAFT_0232320 antibody
DDB_0186762 antibody
DDB_0232320 antibody
Dmel\\CG3299 antibody
Dmvincp antibody
EG:103B4.1 antibody
hm:zehn2160 antibody
im:6902790 antibody
LOC100228062 antibody
MV antibody
MVCL antibody
VCL antibody
vcl-A antibody
Vin antibody
Vin2EF antibody
vinc antibody

Protein level used designations for anti-Vinculin (VCL) Antibodies

metavinculin , vinculin , CG3299-PA , Vinc-PA , vinculin at 2EF , vinculin-like , vinculin/metavinculin

GENE ID	SPECIES
7414	Homo sapiens
783645	Bos taurus
450531	Pan troglodytes
552980	Danio rerio
396974	Sus scrofa
8625369	Dictyostelium discoideum AX4
22330	Mus musculus
31201	Drosophila melanogaster
305679	Rattus norvegicus
396422	Gallus gallus
6047004	Culex quinquefasciatus
6102471	Brugia malayi
100036705	Xenopus (Silurana) tropicalis
100064165	Equus caballus
100228062	Taeniopygia guttata
100357160	Oryctolagus cuniculus
100410985	Callithrix jacchus
100476722	Ailuropoda melanoleuca
479252	Canis lupus familiaris
721921	Macaca mulatta
100075715	Ornithorhynchus anatinus
100302597	Meleagris gallopavo
100583187	Nomascus leucogenys
100722183	Cavia porcellus
373770	Xenopus laevis
100356093	Oryctolagus cuniculus
101121312	Ovis aries

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Show all anti-Vinculin (VCL) Antibodies with Pubmed References