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These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans.
Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores.
enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription.
In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging.
These findings reveal a previously unrecognized but direct link between HP1 (show DEFA1 Proteins) and CPC localization in the centromere and illustrate the critical role of borealin-HP1 (show DEFA1 Proteins) interaction in orchestrating an accurate cell division.
Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C.
MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity.
important role for phosphorylation of Borealin at S219 in the proper progression through mitosis
Data show that INCENP (show INCENP Proteins) has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin (show BIRC5 Proteins) to INCENP (show INCENP Proteins).
Cell cycle-regulated chromosomal passenger protein (show INCENP Proteins) whose aberrant expression and nuclear accumulation are linked to poor prognosis for gastric cancer.
Borr interacts and colocalizes with the ESCRT-III component Shrb in Drosophila cells.
These findings indicate that Borealin plays a key role in liver development, regeneration, and tumorigenesis and suggests that Borealin could be a potential target for related liver diseases.
Borealin plays a crucial role in the early mouse embryonic development
Borealin/DasraB is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53 (show TP53 Proteins)
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16.
, cell division cycle-associated protein 8
, pluripotent embryonic stem cell-related gene 3 protein
, Cell division cycle-associated protein 8
, embryonic stem cell-related
, chromosomal passenger complex protein Dasra B
, cell division cycle associated 8