anti-Human CDKN1B antibody for Intracellular Flow Cytometry

Recommended CDKN1B Antibody (supplied by: Log in to see )

Antigen
Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Antibodies
  • CDKN4
  • KIP1
  • MEN1B
  • MEN4
  • P27KIP1
  • cdkn1b
  • sb:cb611
  • wu:fb63g10
  • wu:fb64g10
  • wu:fe18e03
  • CDKN1B
  • Kip1
  • p27
  • Cdki1b
  • AA408329
  • AI843786
  • p27Kip1
  • cdkn1bl
  • cyclin dependent kinase inhibitor 1B
  • cyclin-dependent kinase inhibitor 1Bb
  • cyclin-dependent kinase inhibitor 1B
  • cyclin-dependent kinase inhibitor 1Ba
  • CDKN1B
  • cdkn1bb
  • Cdkn1b
  • cdkn1ba
Reactivity
Human
789
439
375
182
42
24
18
8
8
7
3
3
2
1
1
1
Host
Rabbit
480
307
37
2
2
1
Clonality
Polyclonal
Conjugate
This CDKN1B antibody is un-conjugated
41
36
35
34
34
29
9
8
8
6
6
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
2
2
2
2
2
2
2
2
1
1
Application
Intracellular Flow Cytometry (ICFC)
629
338
243
233
201
198
101
98
84
55
39
28
14
7
5
3
1
1
Supplier
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Catalog No. ABIN2665312
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General

Antigen Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Antibodies
Reactivity Human
(789), (439), (375), (182), (42), (24), (18), (8), (8), (7), (3), (3), (2), (1), (1), (1)
Host Rabbit
(480), (307), (37), (2), (2), (1)
Clonality (Clone)
Polyclonal   ( )
Conjugate This CDKN1B antibody is un-conjugated
(41), (36), (35), (34), (34), (29), (9), (8), (8), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Intracellular Flow Cytometry (ICFC)
(629), (338), (243), (233), (201), (198), (101), (98), (84), (55), (39), (28), (14), (7), (5), (3), (1), (1)
Pubmed 5 references available
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Product Details anti-CDKN1B Antibody

Target Details CDKN1B Application Details Handling References for anti-CDKN1B antibody (ABIN2665312) Images
Purification The antibody was purified by affinity chromatography.
Clone Poly6029
Isotype IgG
Plasmids, Primers & others

Target Details CDKN1B

Product Details anti-CDKN1B Antibody Application Details Handling References for anti-CDKN1B antibody (ABIN2665312) Images back to top
Antigen
Alternative Name p27Kip1 (CDKN1B Antibody Abstract)
Background P27Kip1 (cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor p27) is a 27kD cyclin-dependent inhibitor. p27Kip1 is localized in the nucleus and cytoplasm (phospho-specific). This protein functions in G1 arrest and binds and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2. p27Kip1 mediates TGF β-induced G1 arrest and regulates cell motility. This kinase has also been implicated in translational control. Akt phosphorylation causes p27 Kip1 export to cytoplasm, p27 Kip1 has also been shown to be ubiquitinated. p27 Kip1 has been shown to interact with NUP50, Skp2, and PKB/Akt. The Poly6029 antibody recognizes the C-terminal region of human p27Kip1 and has been shown to be useful for Western blotting.
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy

Application Details

Product Details anti-CDKN1B Antibody Target Details CDKN1B Handling References for anti-CDKN1B antibody (ABIN2665312) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CDKN1B Antibody Target Details CDKN1B Application Details References for anti-CDKN1B antibody (ABIN2665312) Images back to top
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-CDKN1B antibody (ABIN2665312)

Product Details anti-CDKN1B Antibody Target Details CDKN1B Application Details Handling Images back to top
Background publications

Shi, Wang, Ren, Cheng, Ying, Wu, Lin, Griffin, Li, Moorman, Yao: "KLRG1 impairs CD4+ T cell responses via p16ink4a and p27kip1 pathways: role in hepatitis B vaccine failure in individuals with hepatitis C virus infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 2, pp. 649-57, 2014

Viglietto, Motti, Bruni, Melillo, DAlessio, Califano, Vinci, Chiappetta, Tsichlis, Bellacosa, Fusco, Santoro: "Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer." in: Nature medicine, Vol. 8, Issue 10, pp. 1136-44, 2002

McAllister, Becker-Hapak, Pintucci, Pagano, Dowdy: "Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 216-28, 2002

Millard, Vidal, Markus, Koff: "A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA." in: Molecular and cellular biology, Vol. 20, Issue 16, pp. 5947-59, 2000

Polyak, Lee, Erdjument-Bromage, Koff, Roberts, Tempst, Massagué: "Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals." in: Cell, Vol. 78, Issue 1, pp. 59-66, 1994

Images

Product Details anti-CDKN1B Antibody Target Details CDKN1B Application Details Handling References for anti-CDKN1B antibody (ABIN2665312) back to top
Supplier Images
Western Blotting (WB) image for anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibody (ABIN2665312) anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) antibody