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|Antigen||Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Antibodies|
|Epitope||AA 150-198 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This CDKN1B antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-CDKN1B AntibodyTarget Details CDKN1B Application Details Handling References for anti-CDKN1B antibody (ABIN672621) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human CDKN1B|
|Plasmids, Primers & others|
Target Details CDKN1BProduct Details anti-CDKN1B Antibody Application Details Handling References for anti-CDKN1B antibody (ABIN672621) Images back to top
|Alternative Name||CDKN1B (CDKN1B Antibody Abstract)|
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Subcellular location: Cytoplasm, Nucleus
Synonyms: KIP1, MEN4, CDKN4, MEN1B, P27KIP1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, CDKN1B
|Pathways||Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy|
Application DetailsProduct Details anti-CDKN1B Antibody Target Details CDKN1B Handling References for anti-CDKN1B antibody (ABIN672621) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-CDKN1B Antibody Target Details CDKN1B Application Details References for anti-CDKN1B antibody (ABIN672621) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-CDKN1B antibody (ABIN672621)Product Details anti-CDKN1B Antibody Target Details CDKN1B Application Details Handling Images back to top
|Product cited in:||
Akizuki, Shimobaba, Matsunaga, Endo, Ikari: "Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma." in: Biochimica et biophysica acta, Vol. 1864, Issue 2, pp. 293-302, 2016 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).
Gao, Tang, Ding, Wang, Qi, Wu, Guo: "Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-?B/c-Myc Pathway in Pancreatic ? cells." in: Molecular medicine (Cambridge, Mass.), Vol. 21, Issue 1, pp. 154-66, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).
Sun, Yang, Luo, Wang, Chen, Zhang, Wang, Li: "Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway." in: Theriogenology, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Others).
ImagesProduct Details anti-CDKN1B Antibody Target Details CDKN1B Application Details Handling References for anti-CDKN1B antibody (ABIN672621) back to top