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the 2.5A crystal structure of MPN (show PRSS27 Proteins) domain from Drosophila melanogaster CSN6.
Findings indicate that cops6 plays an anti-apoptotic role during segmentation.
results define a mechanism for the regulation of Myc (show MYC Proteins) stability through the CSN-Cullin-Fbxw7 (show FBXW7 Proteins) axis and provide insights into the correlation of CSN6 overexpression with Myc (show MYC Proteins) stabilization/activation during tumorigenesis
loss of CSN6 enhances p53 (show TP53 Proteins)-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2 (show MDM2 Proteins)-p53 (show TP53 Proteins) signaling pathway
High CSN6 expression is associated with metastasis of glioblastoma.
The overexpression of CSN6 reduced the effect of quercetin treatment on HT29 cells, suggesting that quercetininduced apoptosis may involve the AktCSN6Myc signaling axis in HT29 cells.
CSN6 positively regulates c-Jun (show JUN Proteins) in a MEKK1 (show MAP3K1 Proteins)-dependent manner
our results indicate that CSN6 is a positive regulator of E6AP (show ube3a Proteins) and is important for cervical cancer development.
CSN6 interacts with p27(Kip1 (show CDKN1B Proteins)) and facilitates ubiquitin-mediated degradation of p27(Kip1 (show CDKN1B Proteins)).
Findings indicate that the deregulation of beta-catenin (show CTNNB1 Proteins) by extracellular signal-regulated kinase 2 (ERK2 (show MAPK1 Proteins))-activated CSN6 protein is important for colorectal cancer (CRC (show CALR Proteins)) development.
Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6.
Data suggest that CSN6 is an important negative regulator of p57 (Kip2 (show CDKN1C Proteins)) , and that overexpression of CSN6 in many types of cancer could lead to decreased expression of p57 (Kip2 (show CDKN1C Proteins)) and result in promoted cancer cell growth.
COPS6 is a target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Proteins) 293 cells.
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
COP9 (constitutive photomorphogenic) homolog, subunit 6
, COP9 constitutive photomorphogenic homolog subunit 6
, COP9 signalosome complex subunit 6
, drosophila COP9 signalosome homolog 6
, COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
, COP9 (constitutive photomorphogenic), subunit 6
, COP9 complex S6
, JAB1-containing signalosome subunit 6
, signalosome subunit 6
, COP9 signalosome subunit 6
, COP9 subunit 6 (MOV34 homolog, 34 kD)
, MOV34 homolog, 34 kD
, vpr-interacting protein