anti-Mouse (Murine) COPS8 antibody for ELISA

Recommended COPS8 Antibody (supplied by: Log in to see )

Antigen
COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) Antibodies
  • CG13383
  • CG33297
  • CG42522
  • CH8
  • Csn8
  • Dch8
  • Dmel\\CG42522
  • Dmel_CG13383
  • csn8
  • l(2)SH1829
  • l(2)SH2 1829
  • cops8
  • MGC76051
  • MGC80215
  • DDBDRAFT_0167123
  • DDBDRAFT_0233107
  • DDB_0167123
  • DDB_0233107
  • MGC86182
  • 9430009J09Rik
  • AA408242
  • Sgn8
  • CSN8
  • zgc:56319
  • zgc:86840
  • CONSTITUTIVE PHOTOMORPHOGENIC 9
  • COP9 SIGNALOSOME SUBUNIT 8
  • DL3095C
  • EMB143
  • EMBRYO DEFECTIVE 143
  • FCAALL.131
  • FUS7
  • FUSCA 7
  • FUSCA PROTEIN FUS7
  • COP9
  • SGN8
  • COP9 signalosome subunit 8
  • COP9 signalosome subunit 8 S homeolog
  • COP9 signalosome complex subunit 8
  • COP9 signalosome subunit 8 L homeolog
  • COP9 signalosome, subunit CSN8
  • CSN8
  • cops8
  • COPS8
  • cops8.S
  • csn8
  • cops8.L
  • Cops8
  • COP9
Epitope
C-Term
18
12
11
4
4
4
4
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
75
33
32
3
3
3
3
2
1
1
1
Host
Rabbit
67
8
Clonality
Polyclonal
Conjugate
This COPS8 antibody is un-conjugated
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
55
31
13
10
8
6
2
1
Supplier
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Catalog No. ABIN1002165
$ 523.71
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN6260973 ELISA WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN1030346 ELISA WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN4300073 ELISA WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN5700533 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN1084635 IHC ELISA Rabbit IgG Log in to see Polyclonal 0
1 ABIN2896894 ELISA IHC Rabbit IgG Log in to see Polyclonal 0
1 ABIN1887075 ELISA WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN5897521 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0

General

Antigen COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) Antibodies
Epitope C-Term
(18), (12), (11), (4), (4), (4), (4), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(75), (33), (32), (3), (3), (3), (3), (2), (1), (1), (1)
Host Rabbit
(67), (8)
Clonality
Polyclonal
Conjugate This COPS8 antibody is un-conjugated
(4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Western Blotting (WB)
(55), (31), (13), (10), (8), (6), (2), (1)
Pubmed 4 references available
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Product Details anti-COPS8 Antibody

Target Details COPS8 Application Details Handling References for anti-COPS8 antibody (ABIN1002165) Images
Blocking Peptide Blocking peptide for this product available: ABIN1003775
Purification Affinity chromatography purified via peptide column.
Immunogen CSN8 antibody was raised in rabbits against a 15 amino acid peptide near the carboxy terminus of the human CSN8.
Isotype IgG
Plasmids, Primers & others

Target Details COPS8

Product Details anti-COPS8 Antibody Application Details Handling References for anti-COPS8 antibody (ABIN1002165) Images back to top
Antigen
Alternative Name CSN8 (COP9 signalosome complex subunit 8) (COPS8 Antibody Abstract)
Background The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
Pathways Cell Division Cycle

Application Details

Product Details anti-COPS8 Antibody Target Details COPS8 Handling References for anti-COPS8 antibody (ABIN1002165) Images back to top
Application Notes CSN8 antibody can be used for detection of CSN8 by Western blot at 1 - 2 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only

Handling

Product Details anti-COPS8 Antibody Target Details COPS8 Application Details References for anti-COPS8 antibody (ABIN1002165) Images back to top
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months

References for anti-COPS8 antibody (ABIN1002165)

Product Details anti-COPS8 Antibody Target Details COPS8 Application Details Handling Images back to top
Product cited in:

Wei, Deng: "The COP9 signalosome." in: Annual review of cell and developmental biology, Vol. 19, pp. 261-86, 2003

Uhle, Medalia, Waldron, Dumdey, Henklein, Bech-Otschir, Huang, Berse, Sperling, Schade, Dubiel: "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome." in: The EMBO journal, Vol. 22, Issue 6, pp. 1302-12, 2003

Bech-Otschir, Seeger, Dubiel: "The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis." in: Journal of cell science, Vol. 115, Issue Pt 3, pp. 467-73, 2002

Background publications

Groisman, Polanowska, Kuraoka, Sawada, Saijo, Drapkin, Kisselev, Tanaka, Nakatani: "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage." in: Cell, Vol. 113, Issue 3, pp. 357-67, 2003