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Data show that Islet-1 (ISL1 (show ISL1 Proteins)) activated the expression of cyclin B1 (CCNB1 (show CCNB1 Proteins)), cyclin B2 (CCNB2) and c-myc (c-MYC (show MYC Proteins)) genes by binding to the conserved binding sites on their promoters or enhancers.
Data show that the cyclin B2 was overexpressed in bladder cancer tissue.
overexpression of CCNB2 protein is associated with clinical progression and poor prognosis in non-small cell lung cancer
Cyclin B1 (show CCNB1 Proteins) and cyclin B2 are interchangeable for ability to promote G2 and M transition in HeLa cells.
there was no significance in the 5-year overall survival rates among the patients with squamous cell carcinoma between expressing lower and higher level of cyclin B2 mRNA
Suggest that cytoplasmic CCNB2 may function as an oncogene (show RAB1A Proteins) and could serve as a potential biomarker of unfavorable prognosis over short-term follow-up in breast cancer.
The radiosensitizing effect of paclitaxel on KB cells may be due to the down-regulated expression of PRC1 (show PRC1 Proteins) and cyclin B2.
The relative expression level of circulating CCNB2 mRNA in cancer patients was significantly higher than that in normal controls and benign diseases group. Circulating CCNB2 mRNA level significantly correlated with cancer stage and metastasis status.
Data suggest that cyclin A2 (show CCNA2 Proteins) helps initiate mitosis, in part through its effects on cyclin B1 (show CCNB1 Proteins), and that cyclins B1 and B2 are particularly critical for the maintenance of the mitotic state.
p300 (show EP300 Proteins) binds to multiple NF-Y trimers to regulate cyclin B2 promoter function
Report roles for cyclin B2 and p53 (show TP53 Proteins) in centrosome separation that may be perturbed in many human cancers.
Hec1 (show NDC80 Proteins)-dependent cyclin B2 stabilization during early metaphase is important for early-stage spindle assembly.
Menin may inhibit MEN1 insulinoma (show RPS15 Proteins) by suppressing cyclin B2 expression via histone modification.
this study identifies a correlation between the presence of AIRE (show AIRE Proteins) and proteasomal breakdown of cyclin B2, which leads us to speculate that cyclin B2 could be a target of AIRE's E3-ubiquitin ligase (show MUL1 Proteins) activity
menin-mediated repression of cyclin B2 is crucial for inhibiting G(2)/M transition and cell proliferation through a previously unrecognized molecular mechanism for menin-induced suppression of MEN1 tumorigenesis
an increased CCNB2 expression in human pituitary adenomas of different histotypes that is directly correlated with HMGA1 and HMGA2 expression.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 and cyclin E1 (show CCNE1 Proteins) expression.
These results demonstrate that the proper localization of cyclin B2 is essential for bipolar spindle formation in Xenopus oocytes.
These results show that ElrA and AUF1 (show HNRNPD Proteins) bind to cyclin B2 mRNA independent of cytoplasmic polyadenylation elements and function by binding other elements.
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
, G2/mitotic-specific cyclin B2
, cyclin B2