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The surface immune molecule CD274 (show CD274 Proteins) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (show CD274 Proteins)/JNK (show MAPK8 Proteins)/Cyclin D2 pathway promotes the cell cycle entry of LIC.
High CCND2 expression is associated with Metastasis of Colorectal Cancer.
Mutation in the CCND2 gene is associated with acute myeloid leukemia (show BCL11A Proteins).
data suggested that loss of CCND2 expression is closely associated with the promoter aberrant methylation
MiR (show MLXIP Proteins)-497 significantly suppressed cell proliferation by arresting the cell cycle through the CCND2 protein.
cyclin D2 acts as regulator of cell cycle (show C13orf15 Proteins) proteins affecting SAMHD1 (show SAMHD1 Proteins)-mediated HIV-1 restriction in non-proliferating macrophages.
CCND2-AS1 (show PTGDR Proteins) promotes glioma cells proliferation and growth in a process that involves Wnt (show WNT2 Proteins) and beta-catenin (show CTNNB1 Proteins)
CCND1 (show CCND1 Proteins) is downregulated, whereas CCND2 is not, following ionizing radiation (IR) . Both CCND1 (show CCND1 Proteins)- and CCND2-expressing MM cells arrested in S/G2 (show STRN3 Proteins)/M, and did not differ in other cell-cycle proteins or sensitivity to IR.Differential expression of D-cyclin (show PCNA Proteins) does not appear to affect cell-cycle response to IR, and is unlikely to underlie differential sensitivity to DNA damage.
the phosphorylation levels of ErbB2 (show ERBB2 Proteins), ErbB3 (show ERBB3 Proteins) and Akt (show AKT1 Proteins) and the protein levels of cyclin D1 (show CCND1 Proteins) were decreased by lapatinib treatment of HSC3, HSC4 and Ca9 (show CA9 Proteins)-22 cells
miR (show MLXIP Proteins)-155 overexpression plays a promoting role in the proliferative, migratory and invasive behavior of OSCC cells. Its effects on OSCC are possibly associated with its regulation of the BCL6 (show BCL6 Proteins)/cyclin D2 axis.
Exercise induced cardiac growth in all of the transgenic mice except for the mice deficient in cyclin D2
Cyclin D1 (show CCND1 Proteins) is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 (show CCND1 Proteins) in hematopoiesis.
we analyzed Cyclin D2(-/-) mice to test whether the ciliary margin zone (CMZ)is a source of retinal cells. Neurogenesis is diminished in Cyclin D2 mutants, leading to a reduction of RGCs in the ventral retina. In line with these findings, in the albino retina, the decreased production of ipsilateral RGCs is correlated with fewer Cyclin D2(+) cells.
We showed for the first time that progesterone-induced miR (show MLXIP Proteins)-133a inhibited the proliferation of endometrial epithelial cells by downregulating cyclinD2.
NMB or NMBR silencing inhibited M-CSF (show CSF1R Proteins)/c-Fms (show CSF1R Proteins)-mediated downstream signaling pathways like activation of ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) and induction of D-type cyclins, cyclin D1 (show CCND1 Proteins) and D2.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta (show PRKCZ Proteins)) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (show INS Proteins) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (show FRAP1 Proteins) protein) and Ccnd2 (cyclin-D2).
miR (show MLXIP Proteins)-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2 (show CCNE2 Proteins).
NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r (show IGF1R Proteins)/Insr (show INSR Proteins)-Ccnd2/Ccne1 (show CCNE1 Proteins) plays important roles in myogenesis.
Loss of N-myc (show MYCN Proteins) significantly impairs the Sonic hedgehog (show SHH Proteins) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2.
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 (show PSEN1 Proteins) genes via a STAT3 (show STAT3 Proteins)-dependent pathway
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
, G1/S-specific cyclin-D2
, G1/S-specific cyclin D2
, vin-1 proto-oncogene