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miR (show MLXIP Proteins)-212 exerts growth-suppressive effects in Adult T-cell leukemia/lymphoma (ATL) cells largely by targeting CCND3 and may have therapeutic potential in ATL.
Cyclin D3 is expressed in the majority of splenic diffuse red pulp small B-cell lymphomas. Increased expression is sometimes the result of somatic mutations in the PEST domain of the CCND3 gene.
in ovarian cancer cells, DOT1L (show DOT1L Proteins) regulates the transcription of G1 phase genes CDK6 (show CDK6 Proteins) and CCND3 through H3K79 dimethylation
metabolic function of cyclin D3-CDK6 (show CDK6 Proteins) kinase in cancer cell survival
we showed that ZNF224 (show ZNF224 Proteins) positively modulates cyclin D3 gene expression. Consistently, we observed that alteration of ZNF224 (show ZNF224 Proteins) expression leads to defects in cell cycle control. All together, our results strongly suggest that in Chronic lymphocytic leukaemia (CLL)cells high expression level of ZNF224 (show ZNF224 Proteins) can lead to inappropriate cell growth and apoptosis resistance, thus contributing to CLL progression
the activation of TLR7 (show TLR7 Proteins) increased CCND3 expression via the downregulation of miR (show MLXIP Proteins)-15b in B cells.
This study describes the identification and characterization of cyclin D3 as a novel interactor of influenza A virus M2 protein.
MicroRNA-138 interacts with cyclin D3 and negatively regulates non-small cell lung cancer cells
Combined urinary FGFR3 (show FGFR3 Proteins)/Cyclin D3 expression shows improved detection rates for bladder cancer recurrence with high specificity and sensitivity.
cyclin-D1 (show CCND1 Proteins) and cyclin-D3 within human islet cells varies according to the status of the pancreas donor
The swine UCHL3 (show Uchl3 Proteins), RIT1 (show RIT1 Proteins) and CCND3 genes were found to be differentially expressed in tissues including small intestine, large intestine, liver, muscle, fat, lung, spleen and kidney.
Cyclin D1 (show CCND1 Proteins) is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 (show CCND1 Proteins) in hematopoiesis.
These results suggest that progesterone receptor (show PGR Proteins) overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 (show HOXA10 Proteins) overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction.
immature B and T cells use lymphocyte lineage- and developmental stage-specific mechanisms to inhibit Cyclin D3 protein levels.
we suggest that proper regional decidualization and polyploidy development requires FoxM1 (show FOXM1 Proteins) signaling downstream of Hoxa10 (show HOXA10 Proteins) and cyclin D3.
Cyclin D3 protein that drives immature T cell proliferation is essential for transformation of Atm (show ATM Proteins)-deficient thymocytes
DYRK1A (show DYRK1A Proteins) has a role in lymphopoiesis; Cyclin D3 protein stability is negatively regulated during exit from the proliferative phases of B and T cell development
inactivation of Ccnd3 leads to increased frequencies of lymphocytes with biallelic expression of IgH or TCRbeta genes.
FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.
Results indicate that cyclin D3 plays a cell-autonomous and nonredundant function in regulating the dynamic balance between proliferation, differentiation, and self-renewal that normally establishes an appropriate pool size of adult satellite cells.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
, G1/S-specific cyclin-D3
, D3-type cyclin
, G1/S-specific cyclin D3