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A cyclin I-Cdk5 (show CDK5 Proteins) complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer.
Knockdown of Cyclin I induced cell cycle arrest at S/G2 (show STRN3 Proteins)/M phases.
The increased levels of cyclin I and GDI2 (show GDI2 Proteins) found to be associated with pancreatic carcinoma were further confirmed by Western blot analyses in an independent series of serum samples and/or pancreatic juice samples
Subcellular localization of Cdk5 (show CDK5 Proteins) is determined by its specific activators, cyclin I and p35 (show CDK5R1 Proteins).
Both cyclin I and p35 (show CDK5R1 Proteins) are required for maximal survival benefit of cyclin-dependent kinase 5 (show CDK5 Proteins) in kidney podocytes.
Cyclin I protects podocytes from apoptosis, and we provide preliminary data to suggest that this is mediated by stabilization of p21(Cip1/Waf1 (show CDKN1A Proteins)).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined.
, cyclin ITI