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Hipk2 promotes PP1c-mediated Dvl (show DVL2 Proteins) dephosphorylation via its C-terminal domain and is essential Dvl (show DVL2 Proteins) stability.
Furthermore, our results suggest that modulation of either HIPK2 levels or activity could be exploited to impair NRF2 (show GABPA Proteins)-mediated signalling in cancer cells, and thus sensitise them to chemotherapeutic drugs.
PARP1 (show PARP1 Proteins) can modulate the tumor-suppressing function of HIPK2 by regulating the protein stability of HIPK2.
Data show that HIPK2-T566 phosphorylation contributes to UV-induced HIPK2 activity but it is dispensable for doxorubicin response.
In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7 (show FBXW7 Proteins)-dependent proteasomal degradation of Notch1 (show NOTCH1 Proteins) by phosphorylating its intracellular domain (Notch1 (show NOTCH1 Proteins)-IC) within the Cdc4 (show FBXW7 Proteins) phosphodegron motif.
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 (show HDAC5 Proteins) or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5 (show HDAC5 Proteins)-homeodomain-interacting protein kinase-2-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
These results suggest that the HIPK2-phospho-Ser271 CREB (show CREB1 Proteins) axis is a new arsenic-responsive CREB (show CREB1 Proteins) activation mechanism in parallel with the PKA-phospho-Ser133 CREB (show CREB1 Proteins) axis.
Results demonstrated that HIPK2 may function as a novel regulator to modulate hepatic stellate cells activation, potentially by inhibiting the TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) signaling pathway.
Data show strong reduction of cell viability was induced in vitro and in vivo by the homeodomain interacting protein kinase 2 exon 8 spliced isoform (Hipk2-Deltae8)-specific siRNA, supporting a potential therapeutic application.
Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.
Our findings indicate that phosphorylation-dependent restriction of SIRT1 (show SIRT1 Proteins) activity by HIPK2 shapes the p53 (show TP53 Proteins) response
reveal a previously unrecognized role of HIPK2 activation in ER-stress-mediated neurodegeneration and its potential role as a biomarker and therapeutic target for amyotrophic lateral sclerosis
HIPK2 is ubiquitinated upon heat shock.
Phosphorylation of KLF3 (show KLF3 Proteins) and CtBP2 (show CTBP2 Proteins) by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (show KLF3 Proteins).
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator (show AIRE Proteins) interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Hipk2 has an essential role in mouse white fat development
data identify Hipk2 as a novel regulator of C/EBPbeta (show CEBPB Proteins) and implicate different protein kinases in the cooperation of p300 (show NOTCH1 Proteins) with C/EBPbeta (show CEBPB Proteins) and C/EBPalpha (show CEBPA Proteins)
Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.
Hipk2 is a haploinsufficient tumor suppressor gene for mouse lymphoma development.
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene.
homeodomain interacting protein kinase 2
, serine/threonine protein kinase
, homeodomain-interacting protein kinase 2-like
, homeodomain-interacting protein kinase 2
, homeodomain-interacting protein kinase-2
, nuclear body-associated kinase 1
, sialophorin tail-associated nuclear serine/threonine-protein kinase
, Mx-interacting protein kinase PKM