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Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
investigated the function of the Cdk7 (show CDK7 Proteins).cyclin (show PCNA Proteins) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
This study demonstrates a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism.
study found that Mat1 (show MAT1A Proteins) and Cdk7 (show CDK7 Proteins) levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis
Expressions of components of the CAK complex (show CCNH Proteins), CDK7 (show CDK7 Proteins), MAT1 (show MAT1A Proteins), and Cyclin H (show CCNH Proteins) are elevated in breast cancer.
The intrinsically programmed MAT1 (show MAT1A Proteins) expression and fragmentation regulate granulopoiesis.
The cyclin H (show CCNH Proteins)/cdk7 (show CDK7 Proteins)/Mat1 (show MAT1A Proteins) kinase activity is regulated by CK2 (show CSNK2A1 Proteins) phosphorylation of cyclin H (show CCNH Proteins).
Retinoid-induced G1 arrest and differentiation activation are associated with a switch to enzyme hypophosphorylation of retinoic acid receptor alpha (show RARA Proteins).
interaction with MTA1 (show MTA1 Proteins) and role in regulating estrogen receptor (show ESR1 Proteins) transactivation functions
In response to ATRA, PML (show PML Proteins)/RARalpha (show RARA Proteins) is dissociated from CAK (show CCNH Proteins), leading to MAT1 (show MAT1A Proteins) degradation, G1 arrest, and decreased CAK (show CCNH Proteins) phosphorylation of PML (show PML Proteins)/RARalpha (show RARA Proteins)
Retinoic-acid-induced RAR (show RARA Proteins)-CAK (show CCNH Proteins) signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR (show RARA Proteins)-CAK (show CCNH Proteins) signaling.
These results suggested that genetic variants in CAK (show CCNH Proteins) genes, Cdk7 (show CDK7 Proteins), cyclin H (show CCNH Proteins), MAT1 (show MAT1A Proteins), might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins.
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene.
CDK-activating kinase assembly factor MAT1
, cdk-activating kinase assembly factor mat1
, CDK7/cyclin H assembly factor
, CDK7/cyclin-H assembly factor
, RING finger protein MAT1
, menage a trois 1
, RING finger protein 66
, cyclin G1 interacting protein
, cyclin-G1-interacting protein
, menage a trois 1 (CAK assembly factor)
, menage a trois homolog 1, cyclin H assembly factor