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Authors established a preclinical model of resistance to induction therapy to examine the functional relevance of TFDP3 to chemoresistance in MRD derived from Jurkat/E6-1.
TFDP3 can bind to E2F1 (show E2F1 Proteins) molecule to form E2F (show E2F1 Proteins)/TFDP3 complex; and the localizations of TFDP3 and E2F1 (show E2F1 Proteins) molecules and the co-localization were different in different phases of cell cycle in the nucleus and cytoplasm, which indicated that the E2F (show E2F1 Proteins)/TFDP3 complex involved in the process of regulating the cell cycle.
data highlight that TFDP3 is expressed in breast cancer, that it is a member of the cancer-testis antigen family and that it functions as a regulator in epithelial-mesenchymal transition
TFDP3 was highly expressed in cancer tissues including prostate cancer tissues.TFDP3 was expressed in coordination with E2F1 (show E2F1 Proteins) in most prostate cancer tissues.
Data gathered from cell lines, tumorigenicity studies, and primary hepatocellular carcinoma samples demonstrate a negative role of HIF-2alpha (show EPAS1 Proteins) in tumors, which is mediated by the TFDP3/E2F1 (show E2F1 Proteins) pathway.
Data show that TFDP3 upregulates the expression of autophagy gene LC3B (show MAP1LC3B Proteins) and inhibits E2F1 (show E2F1 Proteins)-induced apoptosis, and may play an important role in prostate cancer.
DP-4 downregulating E2F-1 (show E2F1 Proteins) activity and contributes to a new pRb (show RB1 Proteins)-independent mechanism for regulating cell cycle progression.
TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F (show E2F1 Proteins)
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.
, cancer/testis antigen 30
, hepatocellular carcinoma-associated antigen 661
, transcription factor Dp family member 3
, transcription factor Dp family, member 3