anti-Human TPP1 antibody for Immunohistochemistry

Recommended TPP1 Antibody (supplied by: Log in to see )

Antigen
Tripeptidyl Peptidase I (TPP1) Antibodies
  • cln2
  • fa01b09
  • im:7149243
  • wu:fa01b09
  • CLN2
  • LPIC
  • TPP-1
  • TPP-I
  • Cln2
  • tripeptidyl peptidase I
  • tripeptidyl-peptidase 1
  • tripeptidyl peptidase 1
  • tpp1
  • NAEGRDRAFT_78259
  • MCYG_00184
  • MGYG_05881
  • MGYG_00757
  • TPP1
  • Tpp1
Epitope
AA 195-305
10
9
6
6
5
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
109
31
25
2
2
2
Host
Mouse
80
22
10
Clonality
Monoclonal
Conjugate
This TPP1 antibody is un-conjugated
5
5
4
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
92
38
26
15
13
6
6
5
4
1
1
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Catalog No. ABIN393313
$ 461.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
8.673489 ABIN1871862 ICC IHC WB Rabbit IgG AA 1-320 Log in to see Polyclonal 0
8.673489 ABIN4362561 IHC Rabbit IgG Log in to see Polyclonal 0
1 ABIN441750 ICC IF IHC (p) IHC WB Rabbit IgG Center Log in to see Polyclonal 0
1 ABIN1876828 IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN1833040 IHC IHC (p) WB Rabbit IgG AA 224-563 Log in to see Polyclonal 0
1 ABIN2881185 IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2887313 IHC WB Rabbit Log in to see Polyclonal 0
1 ABIN2799934 IHC (f) IHC (p) IHC WB Rabbit IgG AA 224-563 Log in to see Polyclonal 0
1 ABIN2702173 IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN6107643 ELISA IHC Rabbit IgG AA 196-563 Log in to see Polyclonal 0
1 ABIN2378804 IHC ELISA WB Mouse IgG1 kappa AA 195-305 Log in to see 3B1 0
1 ABIN5697413 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2378798 IHC WB Mouse IgG AA 1-563 Log in to see Polyclonal 0
1 ABIN2378796 IHC ELISA WB Mouse IgG1 kappa AA 195-304 Log in to see 3B1 0
1 ABIN1093936 IHC ELISA WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN1886604 IF IHC WB Rabbit AA 66-294 Log in to see Polyclonal 0
1 ABIN2903893 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2903894 IF/ICC IHC IP WB Rabbit AA 1-320 Log in to see Polyclonal 0
1 ABIN4362560 IHC IHC (p) Rabbit IgG Log in to see Polyclonal 0
1 ABIN2153655 IHC ELISA WB Rabbit IgG Log in to see Polyclonal 0

General

Antigen Tripeptidyl Peptidase I (TPP1) Antibodies
Epitope AA 195-305
(10), (9), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(109), (31), (25), (2), (2), (2)
Host Mouse
(80), (22), (10)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TPP1 antibody is un-conjugated
(5), (5), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(92), (38), (26), (15), (13), (6), (6), (5), (4), (1), (1)
Pubmed 5 references available
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Product Details anti-TPP1 Antibody

Target Details TPP1 Application Details Handling References for anti-TPP1 antibody (ABIN393313) Images
Specificity TPP1 (AAH14863, 195 a.a. ~ 305 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross-Reactivity (Details) Human: ~~ Positive
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: TPP1 (AAH14863, 195 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone 3B1
Isotype IgG1 kappa
Plasmids, Primers & others

Target Details TPP1

Product Details anti-TPP1 Antibody Application Details Handling References for anti-TPP1 antibody (ABIN393313) Images back to top
Antigen
Alternative Name TPP1 (TPP1 Antibody Abstract)
Background

Other Names: Tripeptidyl-peptidase 1, TPP-1, Cell growth-inhibiting gene 1 protein, Lysosomal pepstatin-insensitive protease, LPIC, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase I, TPP-I, TPP1, CLN2

Gene Description: tripeptidyl peptidase I

Gene Summary: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq

Molecular Weight 61248 DA
Gene ID 1200
NCBI Accession NP_000382
UniProt O14773
Pathways Cell Division Cycle, ER-Nucleus Signaling

Application Details

Product Details anti-TPP1 Antibody Target Details TPP1 Handling References for anti-TPP1 antibody (ABIN393313) Images back to top
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Restrictions For Research Use only

Handling

Product Details anti-TPP1 Antibody Target Details TPP1 Application Details References for anti-TPP1 antibody (ABIN393313) Images back to top
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months

References for anti-TPP1 antibody (ABIN393313)

Product Details anti-TPP1 Antibody Target Details TPP1 Application Details Handling Images back to top
Background publications

Souweidane, Fraser, Arkin, Sondhi, Hackett, Kaminsky, Heier, Kosofsky, Worgall, Crystal, Kaplitt: "Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations." in: Journal of neurosurgery. Pediatrics, Vol. 6, Issue 2, pp. 115-22, 2010

Latrick, Cech: "POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation." in: The EMBO journal, Vol. 29, Issue 5, pp. 924-33, 2010

Goldberg-Stern, Halevi, Marom, Straussberg, Mimouni-Bloch: "Late infantile neuronal ceroid lipofuscinosis: a new mutation in Arabs." in: Pediatric neurology, Vol. 41, Issue 4, pp. 297-300, 2009

Autefage, Albinet, Garcia, Berges, Nicolau, Therville, Altié, Caillaud, Levade, Andrieu-Abadie: "Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11507-16, 2009

Kousi, Siintola, Dvorakova, Vlaskova, Turnbull, Topcu, Yuksel, Gokben, Minassian, Elleder, Mole, Lehesjoki: "Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis." in: Brain : a journal of neurology, Vol. 132, Issue Pt 3, pp. 810-9, 2009

Images

Product Details anti-TPP1 Antibody Target Details TPP1 Application Details Handling References for anti-TPP1 antibody (ABIN393313) back to top
Supplier Images
Western Blotting (WB) image for anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (ABIN393313) TPP1 monoclonal antibody (M01), clone 3B1 Western Blot analysis of TPP1 expression in...
Immunohistochemistry (IHC) image for anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (ABIN393313) anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (Image 2)
Western Blotting (WB) image for anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (ABIN393313) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Western Blotting (WB) image for anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (ABIN393313) TPP1 monoclonal antibody (M01), clone 3B1 Western Blot analysis of TPP1 expression in...
Immunohistochemistry (IHC) image for anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (ABIN393313) Immunoperoxidase of monoclonal antibody to TPP1 on formalin-fixed paraffin-embedded h...
ELISA image for anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (ABIN393313) Detection limit for recombinant GST tagged TPP1 is approximately 0.1ng/ml as a captur...