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Human Polyclonal ANKRD1 Primary Antibody for ELISA, WB - ABIN1533905
Umeda-Yano, Hashimoto, Yamamori, Okada, Yasuda, Ohi, Fukumoto, Ito, Takeda: The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia. in Schizophrenia research 2013
Show all 2 Pubmed References
review of CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases [review]
These data suggest that hepatitis C virus coopts ANKRD1 for its own propagation and up-regulation of ANKRD1 may contribute to hepatitis C virus-mediated liver pathogenesis.
To the Ankrd1, it is not responsive to the cardiotoxic drug Doxorubicin, suggesting that different mechanisms govern their expression in cardiac cells.
The association of ANKRD1 with antiapoptotic response suggests its role as myocyte survival factor during late stage heart disease, warranting further studies on ANKRD1 during end-stage heart failure.
Report structure activity relationships for ANKRD1.
ANKRD1 has a significant role in the regulation of apoptosis in human ovarian cancer cells
Augmented CARP expression may be a common molecular event in failing hearts regardless of cardiomyopathic aetiology.
Report impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue.
the 26S proteasome is the dominant regulator of Ankrd1/CARP degradation, and that Ankrd1/CARP half-life is significantly longer in cardiomyocytes (h) than endothelial cells (min).
Ankrd1 and desmin may play important roles in airway smooth muscle cell homeostasis.
Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers.
CARP and its regulator calpain 3 appear to occupy a central position in the important cell fate-governing NF-kappaB pathway in skeletal muscle
p53 operates as an upstream effector of Ankrd1/CARP, by up regulating the proximal ANKRD1 promoter
On the basis of genetic and functional analysis of CARP mutations, ANKRD1 has been identified as a new gene associated with dilated cardiomyopathy, accounting for approximately 2% of the 231 cases studied.
CD45 lateral mobility is regulated by the spectrin-ankyrin cytoskeleton of T cells
Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure.
CARP expression is observed by in situ hybridization in endothelial cells lining human atherosclerotic plaques, whereas lesion macrophages are devoid of CARP; it is induced by activin A in cultured intimal smooth muscle cells.
These findings suggest that type-specific expression patterns of ARPP and CARP are altered in skeletal muscles of amyotrophic lateral sclerosis.
endogenous ANKRD1 and calsequestrin are co-enriched in piglet cardiac Purkinje cells
CARP interacts with itself and desmin. CARP, ankrd2, and DARP contain potential coiled-coil dimerization motifs within their unique aminoterminal domains that mediate the formation of homo-dimers.
The results suggest that CARP can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
Overexpression of Ankrd1 exacerbates pathological cardiac remodeling through the enhancement of cytosolic translocation of CARP and up-regulation of calcineurin.
ANKRD1 modulates inflammatory responses in myoblasts through feedback inhibition of NF-kappaB signaling activity.
ANKRD1 is important for the proper interaction of fibroblasts with a compliant collagenous matrix both in vitro and in vivo
Overexpression of Ankrd1 exacerbates pathological cardiac dysfunction through enhancement of cardiomyocyte apoptosis mediated by the up-regulation of p53.
CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to mechanical pressure overload.
ANKRD1, in association with factors such as nucleolin, represses MMP13 transcription. Ankrd1 deletion additionally relieved MMP10 transcriptional repression
CARP attenuates cardiac hypertrophy, in which the ERK and TGF-beta pathways may be involved. Our findings highlight the significance of CARP as an anti-hypertrophic factor in therapy of cardiac hypertrophy
CARP is expressed during adulthood in response to neurological stimuli, such as kainic acid-induced seizures.
Data show that CARP specific expressed in mouse heart and mainly localized in the nucleus in rat cardiac primary cells.
CARP mRNA expression is detected in an atherosclerotic lesion at the aortic valves of an APOE*3-Leiden mouse after 16 weeks of Western-type diet and is expressed in an intimal smooth muscle cell-rich lesion induced by carotid artery ligation.
dData show that the composition of the titin N2A protein complex is altered in muscular dystrophy with myositis (MDM) by incorporation of CARP, a regulator of the Nkx-2.5-dependent signal pathway
CARP could play a unique role in therapeutic angiogenesis during wound healing.
CARP plays important structural and gene regulatory roles in skeletal muscle.
CARP plays a role in skeletal muscle plasticity
Expression analysis in porcine satellite cells showed that CARP and ANKRD2 were induced in differentiated porcine satellite cells, suggesting a role of them in myogenic differentiation.
CAPZB, ANKRD1, and CTBP2 are promoted as candidate genes for meat quality that provide a link between signal pathways.
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.
ankyrin repeat domain 1 (cardiac muscle)
, cardiac ankyrin repeat protein
, ankyrin repeat domain-containing protein 1
, ankyrin-like repeat protein
, cardiac adriamycin-responsive protein
, cardiac responsive adriamycin protein
, muscle ankyrin repeat protein
, cytokine-inducible gene C-193 protein
, cytokine-inducible nuclear protein
, liver ankyrin repeat domain 1