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|Antigen||CD180 Molecule (CD180) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This CD180 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-CD180 AntibodyTarget Details CD180 Application Details Handling Images
|Specificity||This antibody detects CD180 / RP105 at C-term).|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, mouse|
|Purification||Peptide affinity chromatography|
|Immunogen||RP105 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human RP105.|
|Plasmids, Primers & others|
Target Details CD180Product Details anti-CD180 Antibody Application Details Handling Images back to top
|Alternative Name||CD180 / RP105 (CD180 Antibody Abstract)|
|Background||Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins. One such protein is RP105, a recently identified homolog to TLR4 that, with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. It has also been suggested that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes. Despite its predicted molecular weight, RP105 often migrates at 95 - 105 kDa.Synonyms: LY64, Lymphocyte antigen 64, Radioprotective 105 kDa protein|
|Pathways||Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-CD180 Antibody Target Details CD180 Handling Images back to top
ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD180 Antibody Target Details CD180 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|