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Disruption of GFI1B non-DNA-binding zinc-finger 1 is associated with mild to moderate thrombocytopenia without alpha-granule deficiency or bleeding symptomatology, indicating that the site of GFI1B mutation has important phenotypic implications. Platelet CD34 (show CD34 Proteins) expression appears to be a common feature of perturbed GFI1B function.
Platelet CD34 (show CD34 Proteins) expression and alpha/delta-granule abnormalities in GFI1B- and RUNX1 (show RUNX1 Proteins)-related familial bleeding disorders.
GFI1B is an essential protein for the normal development of the megakaryocyte lineage
High GFI1B expression is associated with small-cell lung cancer.
Results demonstrate that alpha-delta platelet storage pool deficiency is associated with either a heterozygous mutation in GFI1B (de novo or familial) abrogating the binding of the zinc fingers with the promoter of its target genes, or by hypomorphic biallelic mutations leading to autosomal recessive inheritance.
study demonstrates the significance of Gfi1b regulated Kindlin3-Talin1 expression in driving megakaryocytic differentiation and highlights the contribution of cytoskeletal agents in the developmental progression of these platelet progenitors
Role for Alternative GFI1B Splice Variants in Human Hematopoiesis
SPI1 (show SPI1 Proteins)-GFI1B transcriptional network is an important regulatory axis in acute myeloid leukemia (show BCL11A Proteins) as well as in the development of erythroid versus myelomonocytic cell fate
Gfi1b functions as a transcriptional repressor by recruiting histone-modifying enzymes to promoters and enhancers of target genes. Mutations are associated with certain bleeding disorders. Review.
a mutation in GFI1B causes a platelet disorder; GFI1B has a role a critical regulator of platelet shape, number, and function
We demonstrate that overexpression of Gfi1b, c-Fos, and Gata2 (show GATA2 Proteins), previously reported to transdifferentiate fibroblasts into hematopoietic progenitors in vitro, can induce long-term HSC (show FUT1 Proteins) formation in vivo.
We conclude that Gfi1b controls major functions of megakaryocytes such as integrin-dependent cytoskeleton organization, spreading and migration through the regulation of PAK activity whereas the proplatelet formation defect in GFI1B-deficient megakaryocytes is due, at least partially, to an insufficient alpha-tubulin (show TUBA4A Proteins) content.
these results identify Rgs18 (show RGS18 Proteins) as a new and crucial effector of Gfi1b that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices.
Gfi1b is a regulator of embryonic globin expression and embryonic and adult erythroid maturation.
results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene (show RAB1A Proteins) activation in a childhood cancer
Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro.
GFI1B, EVI5, MYB (show MYB Proteins) are additional mouse genes that cooperate with the human BCL6 (show BCL6 Proteins) gene to promote the development of lymphomas.
There is direct yet differential regulation of meis1 (show MEIS1 Proteins) transcription by Gfi1b in distinct hematopoietic lineages.
GFI1 and GFI1B are able to trigger, in the absence of RUNX1 (show RUNX1 Proteins), the down-regulation of endothelial markers and the formation of round cells, a morphologic change characteristic of endothelial to hematopoietic transition.
Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)
, growth factor independent 1B transcription repressor
, growth factor independent protein 1B
, potential regulator of CDKN1A translocated in CML
, zinc finger protein Gfi-1b
, growth factor-independent protein 1B
, zinc finger protein 544
, growth factor independent 1B-like protein
, Zinc finger protein Gfi-1b