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Our results provide evidence for new loci influencing abdominal visceral (BBS9 (show BBS9 Proteins), ADCY8 (show ADCY8 Proteins), KCNK9 (show KCNK9 Proteins)) and subcutaneous (MLLT10 (show MLLT10 Proteins)/DNAJC1/EBLN1 (show EBLN2 Proteins)) fat, and confirmed a locus (THNSL2 (show THNSL2 Proteins)) previously reported to be associated with abdominal fat in women.
ITIH4 (show ITIH4 Proteins) and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4 (show ITIH4 Proteins)(588-930) recombinant fragment
Data suggest that vaspin (show SERPINA12 Proteins) is a ligand for cell-surface GRP78 (show HSPA5 Proteins) (glucose-regulated protein (show HSP90B1 Proteins) 78kD)/MTJ-1 complex; subsequent signal transduction exerts beneficial effects on endoplasmic reticulum stress-induced metabolic dysfunctions as seen in obesity.
In addition to assisting the chaperone GRP78 (show HSPA5 Proteins) in protein quality control in the endoplasmic reticulum, MTJ-1 is essential for transport of GRP78 (show HSPA5 Proteins) to the macrophage surface, which serves a number of functions in immune regulation and signal transduction.
ERj1p coordinates the ribosome at the membrane and allosteric effects may mediate ERj1p's regulatory activity
ERj1p inhibits translation in the absence of BiP (show HSPA5 Proteins), and mediates binding of the nuclear import factor importin beta (show KPNB1 Proteins) and import into the nucleus.
plasma membrane-associated GRP78 (show HSPA5 Proteins) is coupled to pertussis toxin-insensitive Galphaq11 and forms a ternary signaling complex with MTJ-1
May modulate protein synthesis (By similarity).
DnaJ (Hsp40) homolog, subfamily C, member 1
, dnaJ homolog subfamily C member 1
, DnaJ-like protein
, dnaJ protein homolog MTJ1
, DnaJ-like protein 1