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LARP7 knockdown induces progressive time-dependent telomere shortening concomitant with a reduction in telomerase enzymatic activity and a decrease in full-length (catalytically active) TERT (show TERT Proteins) mRNA in vitro, and that humans with LARP7 deficiency display dramatically short telomeres, borderline anemia in younger generations, and anticipation consistent with a telomeropathy.
The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes.
protein HEXIM (show HEXIM1 Proteins) with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE (show MEPCE Proteins) and LARP7.
results suggest that LARP7 uses both its N- and C-terminal domains to stabilize 7SK in a closed structure, which forms by joining conserved sequences at the 5'-end with the foot of the 3' hairpin and has thus functional implications
LARP7 suppresses P-TEFb (show CCNT1 Proteins) activity to inhibit breast cancer progression and metastasis.
LARP7 is most likely recruited to the HIV-1 promoter in the presence of hnRNP A1 (show HNRNPA1 Proteins).
The results demonstrate that the La modules of the human LARP7 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection.
Mediator MED23 (show MED23 Proteins) regulates basal transcription in vivo via an interaction with P-TEFb (show CCNT1 Proteins).
Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism
LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb (show CCNT1 Proteins) dysregulation.
LARP7 interacts with TUT1 (show TUT1 Proteins) nucleotidyl transferase to regulate Lin28 (show LIN28A Proteins) expression.
The balance of Cdk9 (show CDK9 Proteins) and Larp7 plays a key role in cardiomyocyte proliferation and response to injury
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants.
P-TEFb-interaction protein for 7SK stability
, la-related protein 7
, La ribonucleoprotein domain family, member 7
, la-related protein 7-like
, HDCMA18P protein