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Trichostatin A (TSA, a HDAC inhibitor) addition significantly attenuates MTX unsensitivity caused by dysfunction of LMO2/ZEB1 signaling. In conclusion, these findings have identified a molecular mechanism underlying LMO2/ZEB1-mediated leukaemogenesis, paving a way for treating T-ALL with a new strategy of epigenetic inhibitors.
Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1 (show TAL1 Proteins)/LMO2/LDB1 (show LDB1 Proteins) complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
DNM2 (show DNM2 Proteins) mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 (show IL7 Proteins) signalling.
Hhex (show HHEX Proteins) regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
HHEX (show HHEX Proteins) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.
GATA2 (show GATA2 Proteins) and Lmo2 cooperatively regulate VEGF (show VEGFA Proteins)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Proteins).
a regulatory hierarchy of HOX control of LMO2 in normal development
Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.
A model in which the distal control region functions through a chromatin looping mechanism to contact and enhance Lmo2 transcription specifically in erythroid cells.
Studied the solution structure of Lmo2(LIM2 (show LHX2 Proteins)) /Ldb1 (show LDB1 Proteins)(LID) complex. Results show modular binding of tandem LIM (show PDLIM5 Proteins) domains in Lmo2 to tandem linear motifs in Ldb1 (show LDB1 Proteins) is accompanied by several disorder-to-order transitions/ conformational changes in both proteins.
the data in this study revealed a novel crosstalk between LMO2 and the Wnt (show WNT2 Proteins) signaling pathway during tumorigenesis and suggested that LMO2 might be a tumor suppressor in certain solid tumors.
LMO2 has a predominantly cytoplasmic location in breast cancer cells. LMO2 interaction with cofilin1 regulates actin cytoskeleton dynamics, promoting tumor cell invasion and metastasis.
These data indicate that Lhx2 (show LHX2 Proteins) is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 (show LHX2 Proteins) as a new molecular tool for anti-T-ALL drug development.
stromal LMO2 may be responsible for zonal characteristic of Prostate cancer
The transcriptional factor LMO2 regulates endothelial proliferation and angiogenesis in vitro.
This article demonstrates a novel and unexpected function of the LMO2 oncogenic transcription factor in controlling DNA replication that we unravelled via an unbiased proteome-wide screen for LMO2-interacting partners.
Findings suggest that LMO2 loss may be a good predictor for the presence of MYC (show MYC Proteins) translocation in large B-cell lymphoma.
FOXP3 (show FOXP3 Proteins) binds LMO2 in vitro, resulting in decreased interaction between LMO2 and TAL1 (show TAL1 Proteins), providing a molecular mechanism for FOXP3 (show FOXP3 Proteins)-mediated transcriptional modulation in T-ALL.
recurrent activating intronic mutations of LMO2, a prominent oncogene (show RAB1A Proteins) in T-cell acute lymphoblastic leukemia (T-ALL). Heterozygous mutations were identified in PF-382 and DU.528 T-ALL cell lines in addition to 3.7% of pediatric (6 of 160) and 5.5% of adult (9 of 163) T-ALL patient samples.
Data indicate a novel functional mechanism of LMO2 in facilitating the delivery of actin monomers to the branched microfilament and increasing lamellipodia/filopodia formation in basal-type breast cancer cells.
The transcriptional factor LMO2 regulates endothelial proliferation and angiogenesis in vitro. Furthermore, LMO2 is required for angiogenesis and tissue healing in vivo. Thus, LMO2 is a critical determinant of vascular and tissue regeneration.
a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1 (show TAL1 Proteins)-Lmo2-induced haemangioblasts differentiate into endothelial cells
Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated.
Scl (show TAL1 Proteins)/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
, LIM domain only 2 (rhombotin-like 1)
, LIM domain only protein 2
, LIM only 2
, T-cell translocation protein 2
, cysteine-rich protein TTG-2
, T-cell translocation gene 2
, rhombotin 2
, rhombotin-like 1
, LIM domain only-2