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Human Polyclonal MTA3 Primary Antibody for ICC, IF - ABIN250687
Zhang, Stephens, Kumar: Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 5 Pubmed References
The authors demonstrate that the SIX3/LSD1/NuRD(MTA3) complex inhibits carcinogenesis in breast cancer cells and suppresses metastasis in breast cancer.
Results show that metastasis associated 1 family member 3 (MTA3) level was decreased in colorectal cancer and significantly correlated with tumor cell invasion and metastasis, and that MTA3 might serve as a potential marker of tumor recurrence and prognosis of colorectal cancer.
MTA3 is an oncogene of HCC, predicts poor prognosis of HCC, and may be a future marker of HCC treatment.
As a master regulator, MTA3 governs the target selection for nucleosome remodeling and histone deacetylation and functions as a transcriptional repressor. MTA3 dysregulation is associated with tumor progression, invasion, and metastasis in various cancers. MTA is also a key regulator of E-cadherin expression and epithelial-to-mesenchymal transition.
MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A, cyclin D1 and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression
Our results demonstrated that MTA3 overexpression contributes to colorectal cancer carcinogenesis, progression, and chemoresistance. MTA3 could serve as a potential therapeutic target in colorectal cancer
Studies indicate that metastasis associated family, member 3 protein (MTA3) is expressed in various tissues and is associated with different physiological functions, and appears to play more complicated roles in cancers.
role in terminal trophoblast differentiation
MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression.
This review focuses on the current knowledge about the function and regulation of MTA1 and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors.
MAT3 over-expression in non-small cell lung carcinoma and MAT3 mRNA level is a risk factor for lymph node metastasis and survival.
Using western blotting and luciferase assays, MTA3 was identified as a target of miR-495
MTA3 expression is an independent prognostic factor in patients with gastroesophageal junction adenocarcinoma.
Down-regulation of MTA3 and up-regulation of CGB5 and Snail are associated with preeclampsia.
MTA3 is not a useful marker to assess and identify high-risk patients with endometrial adenocarcinomas
The absence of MTA3 leads to aberrant expression of Snail, a master regulator of epithelial to mesenchymal transitions. This results in loss of expression of E-cadherin, causing changes in epithelial architecture and invasive growth.
MTA3 does not repress transcription to a significant level and appears to have a diffused pattern of subcellular localization, suggesting a biological role distinct from that of the other two MTA proteins.
estrogen receptor-alpha regulates metastatic tumor antigen 3 pathway
Molecular dissection of the MTA3 promoter using transient transfection assays identified a composite element required for high-level transcription consisting of an SP1 site in close proximity to a consensus estrogen response element half-site.
a cell type-specific subunit of the corepressor complex Mi-2/NuRD,a cofactor for BCL-6-dependent B cell fate determination.
Findings suggest that Mta3-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.
data are the first to disclose the presence and functional role of MTA3 in the testis, where its expression is regulated by developmental, metabolic, and hormonal cues and is closely associated with steroidogenic dysfunction. The
Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
These results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG repression motif and the NuRD complex.
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (By similarity).
metastasis associated family, member 3
, metastasis associated gene family, member 3
, metastasis-associated protein MTA3
, metastasis associated 1 family, member 3
, metastasis associated 3
, metastasis-associated protein MTA3-like