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These results indicated that low expression of Mda-7/IL-24 (show IL24 Proteins) along with high expression of C-myb are predictors for poor prognosis of Burkitt lymphoma patients; this outcome suggests that Mda-7/IL-24 (show IL24 Proteins) and C-myb might be potential targets for clinical treatment of Burkitt lymphoma.
C-Myb expression in the laryngeal squamous cell carcinoma.YB-1 regulates miR (show MLXIP Proteins)-155 expression via c-Myb in the laryngeal squamous cell carcinoma.
Data indicate a pioneer factor model in which c-Myb binds to regions of closed chromatin and then recruits histone acetyltransferases. By binding to histones, c-Myb facilitates histone acetylation, acting as a cofactor for p300 (show EP300 Proteins) at c-Myb binding sites. The resulting H3K27ac leads to chromatin opening and detachment of c-Myb from the acetylated chromatin.
Both cases harbored the MYB-NFIB (show NFIB Proteins) gene fusion as demonstrated by FISH and RNA-sequencing
Expression of c-Myb, a regulatory factor of B lymphocytes, is increased in B lymphocytes of AIHA/Evans patients, while miR (show MLXIP Proteins)-150 expression is decreased. c-Myb was negatively correlated with miR (show MLXIP Proteins)-150.
genome-wide association analyses identified a new genome-wide significant locus on the HBS1L (show HBS1L Proteins)-MYB intergenic region for platelet-to-lymphocyte ratio
identified a high frequency of MYB rearrangements that promoted the MYB transcriptional activity in BPDCN. MYB split FISH analysis can constitute a valuable diagnostic tool for detecting MYB rearrangements
Studied association of BCL11A single nucleotide polymorphisms(snps) and HBS1L-MYB Intergenic snps with Hereditary Persistence of Fetal Hemoglobin (HPFH) in a cohort of sickle cell patients.
NFIB (show NFIB Proteins)-associated gene rearrangement is a frequent genetic event in vulvar adenoid cystic carcinomas. Chromosome translocations involving NFIB (show NFIB Proteins) but with an intact MYB indicate the presence of novel oncogenic mechanisms for the development of adenoid cystic carcinomas of the vulva.
Expression of the MYB-NFIB (show NFIB Proteins) fusion oncogene (show RAB1A Proteins) in mammary tissue resulted in hyperplastic glands that developed into adenocarcinoma.
This study provides evidence that c-Myb might serve as a new target for the prevention of aminoglycoside-induced hair cells loss.
these results identify a key role for miR (show MLXIP Proteins)-150 in memory CD8 (show CD8A Proteins) T cells through a c-Myb-controlled enhanced survival circuit.
Myb knockdown in Setbp1 (show SETBP1 Proteins) and Setbp1 (show SETBP1 Proteins) missense mutations-induced AML (show RUNX1 Proteins) cells also efficiently induced their differentiation in culture and significantly prolonged the survival of their secondary recipient mice.
These findings reveal miR (show MLXIP Proteins)-301b as a new controller of inflammatory response by repressing c-Myb function to inhibit the anti-inflammatory response to bacterial infection, representing a novel mechanism for balancing inflammation.
The analysis points to a critical role for Hoxa9 (show HOXA9 Proteins) and PU.1 in distal regulation of c-myb expression in murine myeloid cells during iL-6 (show IL6 Proteins)-induced cell differentiation.
Data suggest that the upregulations of Myb and Peg3 are likely the key anti-cancer events of EGCG in vivo.
deficiency alters the expression of a crucial subset of TAL1 (show TAL1 Proteins)- and NOTCH1 (show NOTCH1 Proteins)-regulated genes, including the MYB and MYC (show MYC Proteins) oncogenes, respectively.
MYB acts on MAPK (show MAPK1 Proteins) signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2 (show SPRY2 Proteins).
This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte (show AKAP17A Proteins) development to prevent mistimed dsDNA breaks and their deleterious consequences.
These results Myb as a critical component of the gene regulatory network controlling effector Treg cell differentiation and function.
studies show that merestinib effectively blocks eIF4E phosphorylation in AML (show RUNX1 Proteins) cells and suppresses primitive leukemic progenitors from AML (show RUNX1 Proteins) patients in vitro and in an AML (show RUNX1 Proteins) xenograft model in vivo.
cMyb plays a hitherto unidentified role in dictating physiologic HSPC (show PSMA7 Proteins) migration by modulating Sdf1a (show CXCL12 Proteins) signaling.
show that knockdown of miR (show MYLIP Proteins)-126 results in increased c-Myb levels and promotes erythropoiesis at the expense of thrombopoiesis in vivo
Results suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution.
expression of CD41 and cmyb marks nascent HSCs in the zebrafish AGM (show IGFBP7 Proteins), and provide the means to further dissect HSC (show FUT1 Proteins) generation and
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
c-myb protein (140 AA)
, proto-oncogene c-Myb
, transcriptional activator Myb
, gag-myb protein
, myb proto-oncogene protein
, myeloblastosis proto-oncogene product
, tumor-specific myb protein
, myeloblastosis oncogene
, Avian myeloblastosis viral (v-myb) oncogene homolog
, v-myb myeloblastosis viral oncogene homolog (avian)
, transcriptional activator Myb-like
, DNA-binding transcriptional regulator
, c-myb proto-oncogene
, transcription factor cmyb
, v-myb myeloblastosis viral oncogene homolog
, v-myb avian myeloblastosis viral oncogene homolog