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Human Polyclonal PSIP1 Primary Antibody for IP, WB - ABIN258203
De Rijck, Bartholomeeusen, Ceulemans, Debyser, Gijsbers: High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region. in Nucleic acids research 2010
Show all 7 Pubmed References
Human Polyclonal PSIP1 Primary Antibody for IHC, IP - ABIN258202
Bartholomeeusen, Christ, Hendrix, Rain, Emiliani, Benarous, Debyser, Gijsbers, De Rijck: Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ. in The Journal of biological chemistry 2009
Show all 5 Pubmed References
Human Monoclonal PSIP1 Primary Antibody for IHC (p), ELISA - ABIN564851
Shun, Raghavendra, Vandegraaff, Daigle, Hughes, Kellam, Cherepanov, Engelman: LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. in Genes & development 2007
Human Monoclonal PSIP1 Primary Antibody for ICC, IHC - ABIN969370
Shun, Botbol, Li, Di Nunzio, Daigle, Yan, Lieberman, Lavigne, Engelman: Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. in Journal of virology 2008
Due to its major importance in the early steps of HIV replication, the interaction between IN and LEDGF/p75 has become a pleasing target for anti-HIV drug discovery. The present study involves the finding of novel inhibitor based on the information of dimeric CCD of IN in complex with known inhibitor, which were carried out by applying a structure-based virtual screening concept with molecular docking
structurally conserved IBD-binding motifs (IBMs) on known LEDGF/p75 binding partners can be regulated by phosphorylation, permitting switching between low- and high-affinity states.
findings suggest a novel role of LEDGF/p75 in protecting the unintegrated 3' processed linear HIV-1 cDNA from exonucleolytic degradation.
mono-specific anti-DFS70 antibodies are a strong discriminator between ANA positive healthy controls and patients with systemic autoimmune rheumatic diseases.
Authors report here that the endogenous levels of LEDGF/p75 are upregulated in metastatic castration resistant prostate cancer (mCRPC) cells selected for resistance to the taxane drug docetaxel (DTX).
An important role of PSIP1 in triple negative breast cancer tumorigenicity by promoting the expression of genes that control the cell cycle and tumor metastasis
We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma
The association of LEDGF proteins with the FACT complex and give further support to a role of SSRP1 in HIV-1 infection.
short isoform (p52) of a transcriptional co-activator-PC4 and SF2 interacting protein (Psip1), which is known to be involved in linking transcription to RNA processing, specifically regulates the expression of the lncRNA Hottip-located at the 5' end of the Hoxa locus
Germline polymorphisms in an enhancer of PSIP1 are associated with epithelial ovarian cancer.
PSIP1 likely plays an important role in Hereditary Hearing Loss.
LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer
common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN
Results show that these antibodies are highly specific for dense fine speckles 70 protein DFS70/LEDGFp75 and do not target methyl CpG binding protein 2 (MeCP2).
LEDGF/p75 interacts with splicing factors, contributes to exon choice, and directs HIV-1 integration to transcription units that are highly spliced.
Together, these results provide evidence for an Integrase/Pol mediated uptake of LEDGF/p75 in HIV-1 viral particles and a specific cleavage by HIV protease.
Altogether, these results indicate that a complex containing LEDGF/p75, Iws1, and Spt6 participates in regulating postintegration steps of HIV latency.
LEDGF and 44 other novel putative nuclear targets of human thioredoxin 1 have been identified.
Results of the present work reinforce the association of PSIP1 gene and rs61744944 single nucleotide polymorphism with HIV-1 infection long-term nonprogressors status.
Data show that the same site on integrase-binding domain (IBD) of lens epithelium-derived growth factor (LEDGF) is involved in binding to MLL protein and HIV-IN (integrase), indicating an approach to target LEDGF in both leukemia and HIV infection.
The role of Psip1 in cardiac development
conclude that small peptides disrupting the LEDGF/p75-MLL interface have selective anti-leukemic activity providing a direct rationale for the design of small molecule inhibitors targeting this interaction
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.
Alcohol (ADH) and ALDH dehydrogenases are implicated in cellular detoxification and conversion of vitamin A to RA. Lens epithelium-derived growth factor provides cellular protection against stress by transactivating stress-associated genes.
Results suggest that TNF-alpha elevates the expression of lens epithelium-derived growth factor (LEDGF) and that LEDGF is one of the transactivators of gamma-glutamylcysteine synthetase heavy subunit gene.
These suggest a role for Psip1 in the control of Homeobox expression and may also explain why PSIP1 (LEDGF) is found as a fusion partner with NUP98 in myeloid leukemias.
some DFS70-positive sera have antibodies that recognize antigens of the lens
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).
PC4 and SFRS1 interacting protein 1
, PC4 and SFRS1-interacting protein
, PC4 and SFRS1-interacting protein-like protein
, Lens epithelium-derived growth factor
, PC4 and SFRS1-interacting protein-like
, putative LEDGF/p75 transcription factor
, lens epithelium-derived growth factor
, CLL-associated antigen KW-7
, DFS 70
, dense fine speckles 70 kDa protein
, transcriptional coactivator p52/p75
, transcriptional coactivator p75/p52
, PC4 and SFRS1 interacting protein 2
, dense fine speckles 70
, supercoiled DNA binding protein 75
, lens epithelium derived growth factor p75
, transcription coactivator p75