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SENP2 regulates Drp1 (show CRMP1 ELISA Kits) sumoylation and stability critical for mitochondrial morphogenesis.SENP2 plays role in mitochondria mediated neural degeneration.
This study identified an animal model of SUDEP, which is caused by alteration of a posttranslational protein modification pathway (SUMOylation) on a unique voltage-gated potassium channel (Kv7.2 (show KCNQ2 ELISA Kits)/Kv7.3 (show KCNQ3 ELISA Kits))
These results reveal the important role of SENP2 in the regulation of myostatin (show MSTN ELISA Kits) expression and myogenesis.
SENP2 represses glycolysis and shifts glucose metabolic strategy
Data suggest that SENP2 regulates antiviral innate immunity by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation, and provide an example of cross-talk between the ubiquitin and SUMO pathways in innate immunity.
a mechanism underlying the SENP2-mediated regulation of Mdm2 (show MDM2 ELISA Kits) that is critical for genome integrity in p53 (show TP53 ELISA Kits)-dependent stress responses.
SENP2 de-SUMOylates PPARgamma (show PPARG ELISA Kits) in myotubes, and de-SUMOylation of PPARgamma (show PPARG ELISA Kits) selectively increases the expression of some PPARgamma (show PPARG ELISA Kits) target genes.
Senp2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.
These results establish a critical role for SENP2 in the regulation of adipogenesis by desumoylation.
SUMO-1 protease-1 regulates gene transcription through PML (show PML ELISA Kits).
Data demonstrate that downregulation of SENP2 (show SUMO1 ELISA Kits) is correlated with poor prognosis in bladder cancer; SENP2 (show SUMO1 ELISA Kits) inhibits TGF-beta (show TGFB1 ELISA Kits) signaling and TGF-beta (show TGFB1 ELISA Kits)-induced EMT (show ITK ELISA Kits) of bladder cancer cell; and that its overexpression contributes to suppress bladder cancer cell invasion and metastasis through deSUMOylation of TGF-betaRI.
The variability of the SENP1 and SENP2 genes may play a role in breast cancer occurrence.
SENP2 (show SUMO1 ELISA Kits) inhibits MMP13 (show MMP13 ELISA Kits) expression in BC cells through de-SUMOylation of TBL1 (show TBL1X ELISA Kits)/TBLR1 (show TBL1XR1 ELISA Kits), which inhibits nuclear translocation of beta-catenin (show CTNNB1 ELISA Kits).
miR (show MLXIP ELISA Kits)-181b targets SENP2 (show SUMO1 ELISA Kits) and positively regulated NF-kappaB (show NFKB1 ELISA Kits) activity. NF-kappaB (show NFKB1 ELISA Kits) activation by DNA damage in GBM cells confers resistance to radiation-induced death.
data identify SENP2 as an important regulator of fatty acid metabolism in skeletal muscle
SENP2 (show SUMO1 ELISA Kits) regulates the transcriptional function of MEF2A (show MEF2A ELISA Kits) via direct de-SUMOylation.
p90RSK-mediated SENP2-T368 phosphorylation is a master switch in disturbed-flow-induced signaling.
we show that WWOX required for stabilization of beta-catenin regulated by SENP2 in hepatocellular carcinoma cells
ESR1 repression by SENP2 is independent of its SUMO protease activity.
Many nucleoporins are mislocalized and, in some cases, reduced in level when SENP1 and SENP2 are codepleted.
SUMO1 (UBL1\; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.
SUMO-1 protease 1
, SUMO-1 protease-1
, SUMO-1/Smt3-specific isopeptidase 2
, SUMO/sentrin specific protease 2
, sentrin-specific protease 2
, sentrin/SUMO-specific protease SENP2
, SMT3-specific isopeptidase 2
, SUMO1/sentrin/SMT3 specific protease 2
, Axin-associating molecule
, SUMO/sentrin specific peptidase 2